Major insights into the phylogenetic distribution, biochemistry, and evolutionary significance
of organelles involved in ATP synthesis (energy metabolism) in eukaryotes that thrive in …

The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism.
The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide …

Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Some development stages of the trypanosomatid protozoan parasites are well adapted to in
vitro culture. They can be maintained in rich medium containing large excess of glucose and …

Five years ago, little was known about kinetoplastid evolution. Recent improvements in the
taxon sampling for nuclear rRNA genes and several protein markers have transformed this …

Protozoan Kinetoplastida, including the pathogenic trypanosomatids of the genera
Trypanosoma and Leishmania, compartmentalize several important metabolic systems in …

Ever since the elucidation of the main structural and functional features of eukaryotic cells
and subsequent discovery of the endosymbiotic origin of mitochondria and plastids, two …

Atmospheric oxygen is thought to have played a vital role in the evolution of large, complex
multicellular organisms. Challenging the prevailing theory, we show that the transition from …

The pentose phosphate pathway (PPP) is divided into an oxidative branch that makes
pentose phosphates and a non-oxidative branch that consumes pentose phosphates …

Survival of bloodstream form Trypanosoma brucei, the agent of African sleeping sickness,
normally requires mitochondrial gene expression, despite the absence of oxidative …