Shattering barriers toward clinically meaningful MSC therapies

O Levy, R Kuai, EMJ Siren, D Bhere, Y Milton… - Science …, 2020 - science.org
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

Direct Cell Radiolabeling for in Vivo Cell Tracking with PET and SPECT Imaging

PJ Gawne, F Man, PJ Blower… - Chemical reviews, 2022 - ACS Publications
The arrival of cell-based therapies is a revolution in medicine. However, its safe clinical
application in a rational manner depends on reliable, clinically applicable methods for …

Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies

P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect

UM Fischer, MT Harting, F Jimenez… - Stem cells and …, 2009 - liebertpub.com
Intravenous (IV) stem cell delivery for regenerative tissue therapy has been increasingly
used in both experimental and clinical trials. However, recent data suggest that the majority …

Clinical imaging in regenerative medicine

AV Naumova, M Modo, A Moore, CE Murry… - Nature …, 2014 - nature.com
In regenerative medicine, clinical imaging is indispensable for characterizing damaged
tissue and for measuring the safety and efficacy of therapy. However, the ability to track the …

Stem cell imaging: from bench to bedside

PK Nguyen, J Riegler, JC Wu - Cell stem cell, 2014 - cell.com
Although cellular therapies hold great promise for the treatment of human disease, results
from several initial clinical trials have not shown a level of efficacy required for their use as a …

Assessment and optimization of cell engraftment after transplantation into the heart

JV Terrovitis, RR Smith, E Marbán - Circulation research, 2010 - Am Heart Assoc
Myocardial regeneration using stem and progenitor cell transplantation in the injured heart
has recently become a major goal in the treatment of cardiac disease. Experimental studies …

In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis

A Gholamrezanezhad, S Mirpour, M Bagheri… - Nuclear medicine and …, 2011 - Elsevier
BACKGROUND: Several animal and few human studies suggest the beneficial role of bone
marrow mesenchymal stem cells (MSCs) in liver cirrhosis. However, little is known about the …

Recent advances in positron emission particle tracking: a comparative review

CRK Windows-Yule, MT Herald… - Reports on progress …, 2022 - iopscience.iop.org
Positron emission particle tracking (PEPT) is a technique which allows the high-resolution,
three-dimensional imaging of particulate and multiphase systems, including systems which …

The dark side of the force–constraints and complications of cell therapies for stroke

J Boltze, A Arnold, P Walczak, J Jolkkonen… - Frontiers in …, 2015 - frontiersin.org
Cell therapies are increasingly recognized as a promising option to augment the limited
therapeutic arsenal available to fight ischemic stroke. During the last two decades …