Fungal drug response and antimicrobial resistance

P Osset-Trénor, A Pascual-Ahuir, M Proft - Journal of Fungi, 2023 - mdpi.com
Antifungal resistance is a growing concern as it poses a significant threat to public health.
Fungal infections are a significant cause of morbidity and mortality, especially in …

How fungal multidrug transporters mediate hyper resistance through DNA amplification and mutation

A Banerjee, H Rahman, R Prasad… - Molecular …, 2022 - Wiley Online Library
A significant portion of clinically observed antifungal resistance is mediated by ATP‐binding
cassette (ABC) and major facilitator superfamily (MFS) transport pumps that reside in the …

Molecular Response of Meyerozyma guilliermondii to Patulin: Transcriptomic-Based Analysis

Q Yang, X Zhang, D Solairaj, Y Fu, H Zhang - Journal of Fungi, 2023 - mdpi.com
Patulin (PAT), mainly produced by Penicillium expansum, is a potential threat to health. In
recent years, PAT removal using antagonistic yeasts has become a hot research topic …

[HTML][HTML] Cytostatic effects of structurally different ginsenosides on yeast cells with altered sterol biosynthesis and transport

SS Sokolov, PE Volynsky, OT Zangieva… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Triterpene glycosides are a diverse group of plant secondary metabolites, consisting of a
sterol-like aglycon and one or several sugar groups. A number of triterpene glycosides show …

Loss of the yeast transporter Agp2 upregulates the pleiotropic drug-resistant pump Pdr5 and confers resistance to the protein synthesis inhibitor cycloheximide

Y Manzoor, M Aouida, R Ramadoss… - Plos one, 2024 - journals.plos.org
The transmembrane protein Agp2, initially shown as a transporter of L-carnitine, mediates
the high-affinity transport of polyamines and the anticancer drug bleomycin-A5. Cells lacking …

Exploring the biological function of efflux pumps for the development of superior industrial yeasts

I Sá-Correia, CP Godinho - Current Opinion in Biotechnology, 2022 - Elsevier
Highlights•Multidrug/multixenobiotic resistance (MDR/MXR) involves plasma membrane
ABC and MFS efflux pumps.•Engineering of these transporters is a promising strategy for the …

Acquired Triazole Resistance Alters Pathogenicity-Associated Features in Candida auris in an Isolate-Dependent Manner

F Bohner, C Papp, T Takacs, M Varga, A Szekeres… - Journal of Fungi, 2023 - mdpi.com
Fluconazole resistance is commonly encountered in Candida auris, and the yeast frequently
displays resistance to other standard drugs, which severely limits the number of effective …

The Imidazolium Ionic Liquids Toxicity is Due to Their Effect on the Plasma Membrane

SS Sokolov, EA Smirnova, TI Rokitskaya… - Biochemistry (Moscow …, 2024 - Springer
Ionic liquids (ILs) are organic salts with a low melting point. This is due to the fact that their
alkyl side chains, which are covalently connected to the ion, hinder the crystallization of ILs …

[PDF][PDF] Final Degree Project

CN Villarreal - zaguan.unizar.es
Candida genus species are opportunistic fungi causing candidiasis, whose prevalence is on
a growing trend. C. albicans is the commonest yeast causing opportunistic fungal diseases …