Synergistic effects of multiple rotors and hydrogen-bond interactions lead to sensitive near-infrared viscosity probes for live-cell microscopy

D Li, T Shen, X Xue, W Chen, W Tao, W Chi… - Science China …, 2023 - Springer
Abstract Changes in cellular viscosity are associated with various physiological processes
and pathological conditions. To study these cellular processes and functions, highly …

The significant role of the microfilament system in tumors

X Jiang, Y Qin, L Kun, Y Zhou - Frontiers in oncology, 2021 - frontiersin.org
Actin is the structural protein of microfilaments, and it usually exists in two forms: monomer
and polymer. Among them, monomer actin is a spherical molecule composed of a …

Recent advances on the model, measurement technique, and application of single cell mechanics

H Huang, C Dai, H Shen, M Gu, Y Wang, J Liu… - International Journal of …, 2020 - mdpi.com
Since the cell was discovered by humans, it has been an important research subject for
researchers. The mechanical response of cells to external stimuli and the biomechanical …

[HTML][HTML] Differential regulation of GUV mechanics via actin network architectures

NH Wubshet, B Wu, S Veerapaneni, AP Liu - Biophysical Journal, 2023 - cell.com
Actin networks polymerize and depolymerize to construct highly organized structures,
thereby endowing the mechanical phenotypes found in a cell. It is generally believed that …

High shear stress amplitude in combination with prolonged stimulus duration determine induction of osteoclast formation by hematopoietic progenitor cells

C Bratengeier, A Liszka, J Hoffman… - The FASEB …, 2020 - Wiley Online Library
To date, it is unclear how fluid dynamics stimulate mechanosensory cells to induce an
osteoprotective or osteodestructive response. We investigated how murine hematopoietic …

A high-throughput microfabricated platform for rapid quantification of metastatic potential

S Bhattacharya, A Ettela, J Haydak, CM Hobson… - Science …, 2024 - science.org
Assays that measure morphology, proliferation, motility, deformability, and migration are
used to study the invasiveness of cancer cells. However, native invasive potential of cells …

Biomechanical heterogeneity of living cells: comparison between atomic force microscopy and finite element simulation

G Tang, M Galluzzi, B Zhang, YL Shen, FJ Stadler - Langmuir, 2018 - ACS Publications
Atomic force microscopy (AFM) indentation is a popular method for characterizing the
micromechanical properties of soft materials such as living cells. However, the mechanical …

Cytoplasmic viscosity is a potential biomarker for metastatic breast cancer cells

M Dessard, JB Manneville, JF Berret - Nanoscale Advances, 2024 - pubs.rsc.org
Cellular microrheology has shown that cancer cells with high metastatic potential are softer
compared to non-tumorigenic normal cells. These findings rely on measuring the apparent …

Characterization of the viscoelastic properties of ovarian cancer cells membranes by optical tweezers and quantitative phase imaging

T Lu, B Anvari - Frontiers in physics, 2020 - frontiersin.org
Ovarian cancer is the deadliest gynecological cancer in women. It is a highly metastatic
disease with pelvis, regional lymph nodes, and peritoneal cavity as major sites for tumor …

Modulating cancer cell mechanics and actin cytoskeleton structure by chemical and mechanical stimulations

S Azadi, M Tafazzoli‐Shadpour… - … Research Part A, 2019 - Wiley Online Library
To date, a myriad of strategies has been suggested for targeting the chemical signaling of
cancer cells. Also, biomechanical features are gaining much more attention. These features …