[HTML][HTML] Tolerance and resistance of Pseudomonas aeruginosa biofilms to antimicrobial agents—how P. aeruginosa can escape antibiotics

O Ciofu, T Tolker-Nielsen - Frontiers in microbiology, 2019 - frontiersin.org
Pseudomonas aeruginosa is one of the six bacterial pathogens, Enterococcus faecium,
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …

Biotechnological domestication of pseudomonads using synthetic biology

PI Nikel, E Martínez-García, V De Lorenzo - Nature Reviews …, 2014 - nature.com
Much of contemporary synthetic biology research relies on the use of bacterial chassis for
plugging-in and plugging-out genetic circuits and new-to-nature functionalities. However …

Reconfiguration of metabolic fluxes in Pseudomonas putida as a response to sub-lethal oxidative stress

PI Nikel, T Fuhrer, M Chavarría… - The ISME …, 2021 - academic.oup.com
As a frequent inhabitant of sites polluted with toxic chemicals, the soil bacterium and plant-
root colonizer Pseudomonas putida can tolerate high levels of endogenous and exogenous …

Stress-induced mutagenesis in bacteria

PL Foster - Critical reviews in biochemistry and molecular biology, 2007 - Taylor & Francis
Bacteria spend their lives buffeted by changing environmental conditions. To adapt to and
survive these stresses, bacteria have global response systems that result in sweeping …

The metabolic redox regime of Pseudomonas putida tunes its evolvability toward novel xenobiotic substrates

Ö Akkaya, DR Pérez-Pantoja, B Calles, PI Nikel… - MBio, 2018 - Am Soc Microbiol
During evolution of biodegradation pathways for xenobiotic compounds involving Rieske
nonheme iron oxygenases, the transition toward novel substrates is frequently associated …

Stress-induced mutagenesis and complex adaptation

Y Ram, L Hadany - Proceedings of the Royal Society B …, 2014 - royalsocietypublishing.org
Because mutations are mostly deleterious, mutation rates should be reduced by natural
selection. However, mutations also provide the raw material for adaptation. Therefore …

The divergence of mutation rates and spectra across the Tree of Life

M Lynch, F Ali, T Lin, Y Wang, J Ni, H Long - EMBO reports, 2023 - embopress.org
Owing to advances in genome sequencing, genome stability has become one of the most
scrutinized cellular traits across the Tree of Life. Despite its centrality to all things biological …

A role for the stringent response in ciprofloxacin resistance in Pseudomonas aeruginosa

L García-Villada, NP Degtyareva, AM Brooks… - Scientific Reports, 2024 - nature.com
Pseudomonas aeruginosa is a major cause of nosocomial infections and the leading cause
of chronic lung infections in cystic fibrosis and chronic obstructive pulmonary disease …

The evolution of stress-induced hypermutation in asexual populations

Y Ram, L Hadany - Evolution, 2012 - academic.oup.com
Numerous empirical studies show that stress of various kinds induces a state of
hypermutation in bacteria via multiple mechanisms, but theoretical treatment of this …

Narrative of a versatile and adept species Pseudomonas putida

M Kivisaar - Journal of medical microbiology, 2020 - microbiologyresearch.org
Pseudomonas putida is a fast-growing bacterium found mostly in temperate soil and water
habitats. The metabolic versatility of P. putida makes this organism attractive for …