Strong elastic protein nanosheets enable the culture and differentiation of induced pluripotent stem cells on microdroplets

E Mojares, C Nadal, D Hayler, H Kanso… - Advanced …, 2024 - Wiley Online Library
Advances in stem cell technologies, revolutionizing regenerative therapies and advanced in
vitro testing, require novel cell manufacturing pipelines able to cope with scale up and …

Biofabrication and biomanufacturing in Ireland and the UK

JF Murphy, M Lavelle, L Asciak, R Burdis… - Bio-Design and …, 2024 - Springer
As we navigate the transition from the Fourth to the Fifth Industrial Revolution, the emerging
fields of biomanufacturing and biofabrication are transforming life sciences and healthcare …

Growth of mesenchymal stem cells at the surface of silicone, mineral and plant-based oils

L Peng, C Nadal, JE Gautrot - Biomedical Materials, 2023 - iopscience.iop.org
Bioemulsions are attractive platforms for the expansion of adherent cells in bioreactors.
Their design relies on the self-assembly of protein nanosheets at liquid–liquid interfaces …

[HTML][HTML] Programmed Self-Assembly of DNA Nanosheets with Discrete Single-Molecule Thickness and Interfacial Mechanics: Design, Simulation, and …

K Cervantes-Salguero, YA Gutiérrez Fosado… - Molecules, 2023 - mdpi.com
DNA is programmed to hierarchically self-assemble into superstructures spanning from
nanometer to micrometer scales. Here, we demonstrate DNA nanosheets assembled out of …

Regulation of Tendon Stem Cell Behavior by Designed Nanoporous Topography of Microfibers

Y Ye, Y Xu, Y Hou, D Yin, D Su, Z Zhao - Biomacromolecules, 2023 - ACS Publications
Nano scale topography scaffold is more bioactive and biomimetic than smooth fiber
topographies. Tendon stem cells (TSCs) play important roles in the tendinogenesis of …

[HTML][HTML] Interfacial mechanics of β-casein and albumin mixed protein assemblies at liquid-liquid interfaces

A Chrysanthou, M Bosch-Fortea, C Nadal… - Journal of Colloid and …, 2024 - Elsevier
Protein emulsifiers play an important role in formulation science, from food product
development to emerging applications in biotechnologies. The impact of mixed protein …

Matrix Nanoscale Mechanics Regulates Exosome Production by Mesenchymal Stem Cells

A Chrysanthou, JE Gautrot - Biorxiv, 2023 - biorxiv.org
Complex biotherapeutics such exosomes offer attractive opportunities for cell-free treatment
of disease and conditions difficult to address with single, defined compounds. However their …

Strong Elastic Protein Nanosheets Enable the Culture and Differentiation of Induced Pluripotent Stem Cells on Microdroplets

E Mojares, A Chrysanthou, JE Gautrot - bioRxiv, 2023 - biorxiv.org
Advances in stem cell technologies, revolutionising regenerative therapies and advanced in
vitro testing, require novel cell manufacturing pipelines able to cope with scale up and …

Biomimetic Artificial Bone Marrow Niches for the Scale Up of Hematopoietic Stem Cells

J Gautrot, M Bosch-Fortea, D Marciano - 2023 - researchsquare.com
Hematopoietic stem cell (HSC) transplantation to treat haematological disorders is greatly
restricted by poor cell availability. Ex vivo expansion of HSCs as a strategy to overcome this …

The mechanical anisotropy of adipose tissues regulates ovarian cancer invasion

J Gonzalez-Molina, P Nabili, D Marciano, S Abdelnabi… - bioRxiv, 2024 - biorxiv.org
High-grade serous ovarian cancer, the most common and aggressive form of ovarian
cancer, generally metastasises to visceral adipose tissues. In these tissues, the extracellular …