Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

MS de Almeida, E Susnik, B Drasler… - Chemical society …, 2021 - pubs.rsc.org
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …

Emerging applications of nanotechnology in healthcare and medicine

S Malik, K Muhammad, Y Waheed - Molecules, 2023 - mdpi.com
Knowing the beneficial aspects of nanomedicine, scientists are trying to harness the
applications of nanotechnology in diagnosis, treatment, and prevention of diseases. There …

The dose threshold for nanoparticle tumour delivery

B Ouyang, W Poon, YN Zhang, ZP Lin, BR Kingston… - Nature materials, 2020 - nature.com
Nanoparticle delivery to solid tumours over the past ten years has stagnated at a median of
0.7% of the injected dose. Varying nanoparticle designs and strategies have yielded only …

Why nanoparticles prefer liver macrophage cell uptake in vivo

W Ngo, S Ahmed, C Blackadar, B Bussin, Q Ji… - Advanced Drug Delivery …, 2022 - Elsevier
Effective delivery of therapeutic and diagnostic nanoparticles is dependent on their ability to
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

AG Solis, P Bielecki, HR Steach, L Sharma… - Nature, 2019 - nature.com
Direct recognition of invading pathogens by innate immune cells is a critical driver of the
inflammatory response. However, cells of the innate immune system can also sense their …

[HTML][HTML] Extracellular vesicle-based drug delivery systems for cancer treatment

S Walker, S Busatto, A Pham, M Tian, A Suh… - Theranostics, 2019 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are naturally occurring cell-secreted nanoparticles that play
important roles in many physiological and pathological processes. EVs enable intercellular …

Clinical cancer nanomedicine

J Wolfram, M Ferrari - Nano today, 2019 - Elsevier
Nanotechnology offers new solutions for the development of cancer therapeutics that display
improved efficacy and safety. Although several nanotherapeutics have received clinical …

Insights from nanomedicine into chloroquine efficacy against COVID-19

TY Hu, M Frieman, J Wolfram - Nature nanotechnology, 2020 - nature.com
Insights from nanomedicine into chloroquine efficacy against COVID-19 | Nature
Nanotechnology Skip to main content Thank you for visiting nature.com. You are using a …

Autophagy as a molecular target for cancer treatment

NM Kocaturk, Y Akkoc, C Kig, O Bayraktar… - European Journal of …, 2019 - Elsevier
Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …

Overcoming the reticuloendothelial system barrier to drug delivery with a “don't-eat-us” strategy

Y Tang, X Wang, J Li, Y Nie, G Liao, Y Yu, C Li - ACS nano, 2019 - ACS Publications
Overcoming the reticuloendothelial system (RES) has long been a vital challenge to
nanoparticles as drug carriers. Modification of nanoparticles with polyethylene glycol helps …