Integrins are transmembrane proteins that mediate cellular adhesion and migration to
neighboring cells or the extracellular matrix, which is essential for cells to undertake diverse …

Integrins are heterodimeric glycoproteins crucial to the physiology and pathology of many
biological functions. As adhesion molecules, they mediate immune cell trafficking, migration …

Integrins are a family of cell surface receptors crucial to fundamental cellular functions such
as adhesion, signaling, and viability, deeply involved in a variety of diseases, including the …

Tailor-made AAs are indispensable components of modern medicinal chemistry and are
becoming increasingly prominent in new drugs. In fact, about 30% of small-molecule …

Despite significant advances in the understanding of cancer biology, cancer is still a leading
cause of death worldwide. Expression of the tumor microenvironment component …

α4β1 integrin is a cell adhesion receptor deeply involved in the migration and accumulation
of leukocytes. Therefore, integrin antagonists that inhibit leukocytes recruitment are currently …

Over the last four decades, methodological innovations have continuously changed
transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs …

Dry eye disease (DED) is a complex multifactorial disease showing heterogenous
symptoms, including dryness, photophobia, ocular discomfort, irritation and burning but also …

CD11d/CD18 is the most recently discovered and least understood β2 integrin. Known
CD11d adhesive mechanisms contribute to both extravasation and mesenchymal migration …

Background Gastric cancer is one of the deadliest cancers, currently available therapies
have limited success. Cancer-associated fibroblasts (CAFs) are pivotal cells in the stroma of …