Extending the “one strain many compounds”(OSMAC) principle to marine microorganisms

S Romano, SA Jackson, S Patry, ADW Dobson - Marine drugs, 2018 - mdpi.com
Genomic data often highlights an inconsistency between the number of gene clusters
identified using bioinformatic approaches as potentially producing secondary metabolites …

Machine learning in bioprocess development: from promise to practice

LM Helleckes, J Hemmerich, W Wiechert… - Trends in …, 2023 - cell.com
Fostered by novel analytical techniques, digitalization, and automation, modern bioprocess
development provides large amounts of heterogeneous experimental data, containing …

Bioprocessing in the digital age: the role of process models

H Narayanan, MF Luna, M von Stosch… - Biotechnology …, 2020 - Wiley Online Library
In this age of technology, the vision of manufacturing industries built of smart factories is not
a farfetched future. As a prerequisite for Industry 4.0, industrial sectors are moving towards …

[HTML][HTML] Automation and artificial intelligence in filamentous fungi-based bioprocesses: A review

S Wainaina, MJ Taherzadeh - Bioresource Technology, 2023 - Elsevier
By utilizing their powerful metabolic versatility, filamentous fungi can be utilized in
bioprocesses aimed at achieving circular economy. With the current digital transformation …

Recent advances in fed-batch microscale bioreactor design

S Teworte, K Malcı, LE Walls, M Halim… - Biotechnology …, 2022 - Elsevier
Advanced fed-batch microbioreactors mitigate scale up risks and more closely mimic
industrial cultivation practices. Recently, high throughput microscale feeding strategies have …

Enabling high‐throughput biology with flexible open‐source automation

EJ Chory, DW Gretton, EA DeBenedictis… - Molecular systems …, 2021 - embopress.org
Our understanding of complex living systems is limited by our capacity to perform
experiments in high throughput. While robotic systems have automated many traditional …

Development of novel bioreactor control systems based on smart sensors and actuators

B Wang, Z Wang, T Chen, X Zhao - Frontiers in bioengineering and …, 2020 - frontiersin.org
Bioreactors of various forms have been widely used in environmental protection, healthcare,
industrial biotechnology, and space exploration. Robust demand in the field stimulated the …

Synthetic biology for bioengineering virus‐like particle vaccines

HK Charlton Hume, J Vidigal… - Biotechnology and …, 2019 - Wiley Online Library
Vaccination is the most effective method of disease prevention and control. Many viruses
and bacteria that once caused catastrophic pandemics (eg, smallpox, poliomyelitis …

Engineering interventions in enzyme production: Lab to industrial scale

A Tarafdar, R Sirohi, VK Gaur, S Kumar, P Sharma… - Bioresource …, 2021 - Elsevier
Commercial enzyme production has gained popularity due to its extensive applications in
traditional and modern industrial sectors. Rigorous research activities are being conducted …

Microbial microdroplet culture system (MMC): An integrated platform for automated, high‐throughput microbial cultivation and adaptive evolution

X Jian, X Guo, J Wang, ZL Tan, X Xing… - Biotechnology and …, 2020 - Wiley Online Library
Conventional microbial cell cultivation techniques are typically labor intensive, low
throughput, and poorlyparallelized, rendering them inefficient. The development of …