The Escherichia coli chemotaxis signaling pathway has served as a model system for the
adaptive sensing of environmental signals by large protein complexes. The chemoreceptors …

For continuous-time Markov chains and open unimolecular chemical reaction networks, we
prove that any two stationary currents are linearly related upon perturbations of a single …

We study the energy cost of flocking in the active Ising model (AIM) and show that, besides
the energy cost for self-propelled motion, an additional energy dissipation is required to …

Cleavage of dinucleotides after the misincorporational pauses serves as a proofreading
mechanism that increases transcriptional elongation accuracy. The accuracy is further …

Biological processes such as DNA replication, RNA transcription, and protein translation
operate with remarkable speed and accuracy in selecting the right substrate from pools of …

Polymers consisting of more than one type of monomer, known as copolymers, are vital to
both living and synthetic systems. Copolymerization has been studied theoretically in a …

Cellular signaling, crucial for biological processes like immune response and homeostasis,
relies on specificity and fidelity in signal transduction to accurately respond to stimuli amidst …

The metabolic efficiency of mammalian cells depends on the attenuation of intrinsic
translation noise by microRNAs. We devised a metric of cellular metabolic rate (cMR) …

We derive a universal lower bound on the Fano factors of general biochemical
discriminatory networks involving irreversible catalysis steps, based on the thermodynamic …

Nonequilibrium systems, in particular living organisms, are maintained by irreversible
transformations of energy that drive diverse functions. Quantifying their irreversibility, as …