Unsupervised and semi‐supervised learning: The next frontier in machine learning for plant systems biology

J Yan, X Wang - The Plant Journal, 2022 - Wiley Online Library
Advances in high‐throughput omics technologies are leading plant biology research into the
era of big data. Machine learning (ML) performs an important role in plant systems biology …

Learning to optimize: reference vector reinforcement learning adaption to constrained many-objective optimization of industrial copper burdening system

L Ma, N Li, Y Guo, X Wang, S Yang… - IEEE Transactions …, 2021 - ieeexplore.ieee.org
The performance of decomposition-based algorithms is sensitive to the Pareto front shapes
since their reference vectors preset in advance are not always adaptable to various problem …

Clustering single-cell RNA-seq data with a model-based deep learning approach

T Tian, J Wan, Q Song, Z Wei - Nature Machine Intelligence, 2019 - nature.com
Single-cell RNA sequencing (scRNA-seq) promises to provide higher resolution of cellular
differences than bulk RNA sequencing. Clustering transcriptomes profiled by scRNA-seq …

Model-based deep embedding for constrained clustering analysis of single cell RNA-seq data

T Tian, J Zhang, X Lin, Z Wei, H Hakonarson - Nature communications, 2021 - nature.com
Clustering is a critical step in single cell-based studies. Most existing methods support
unsupervised clustering without the a priori exploitation of any domain knowledge. When …

Deep structural clustering for single-cell RNA-seq data jointly through autoencoder and graph neural network

Y Gan, X Huang, G Zou, S Zhou… - Briefings in …, 2022 - academic.oup.com
Single-cell RNA sequencing (scRNA-seq) permits researchers to study the complex
mechanisms of cell heterogeneity and diversity. Unsupervised clustering is of central …

SinNLRR: a robust subspace clustering method for cell type detection by non-negative and low-rank representation

R Zheng, M Li, Z Liang, FX Wu, Y Pan, J Wang - Bioinformatics, 2019 - academic.oup.com
Motivation The development of single-cell RNA-sequencing (scRNA-seq) provides a new
perspective to study biological problems at the single-cell level. One of the key issues in …

Self-supervised contrastive learning for integrative single cell RNA-seq data analysis

W Han, Y Cheng, J Chen, H Zhong, Z Hu… - Briefings in …, 2022 - academic.oup.com
We present a novel self-supervised Contrastive LEArning framework for single-cell
ribonucleic acid (RNA)-sequencing (CLEAR) data representation and the downstream …

Consensus clustering of single-cell RNA-seq data by enhancing network affinity

Y Cui, S Zhang, Y Liang, X Wang… - Briefings in …, 2021 - academic.oup.com
Elucidation of cell subpopulations at high resolution is a key and challenging goal of single-
cell ribonucleic acid (RNA) sequencing (scRNA-seq) data analysis. Although unsupervised …

A data-driven clustering recommendation method for single-cell RNA-sequencing data

Y Tian, R Zheng, Z Liang, S Li… - Tsinghua Science and …, 2021 - ieeexplore.ieee.org
Recently, the emergence of single-cell RNA-sequencing (scRNA-seq) technology makes it
possible to solve biological problems at the single-cell resolution. One of the critical steps in …

A riemannian admm

J Li, S Ma, T Srivastava - arXiv preprint arXiv:2211.02163, 2022 - arxiv.org
We consider a class of Riemannian optimization problems where the objective is the sum of
a smooth function and a nonsmooth function, considered in the ambient space. This class of …