The incidence of fungal infections has increased significantly, so contributing to morbidity
and mortality. This is caused by an increase in antimicrobial resistance and the restricted …

The AMP-activated protein kinase (AMPK) functions to monitor and maintain energy
homeostasis at the cellular and organism level. AMPK was perceived historically primarily …

Recent developments in proteomics have enabled signaling studies where> 10,000
phosphosites can be routinely identified and quantified. Yet, current analyses are limited in …

For the yeast Saccharomyces cerevisiae, nutrient limitation is a key developmental signal
causing diploid cells to switch from yeast-form budding to either foraging pseudohyphal (PH) …

The protein kinase Hog1 (high osmolarity glycerol 1) was discovered 20 years ago, being
revealed as a central signaling mediator during osmoregulation in the budding yeast …

Candida sp. are among the most common fungal commensals found in the human
microbiome. Although Candida can be found residing harmlessly on the surface of the skin …

Copy number variants (CNVs) are a pervasive source of genetic variation and evolutionary
potential, but the dynamics and diversity of CNVs within evolving populations remain …

G-protein signalling pathways are involved in sensing the environment, enabling fungi to
coordinate cell function, metabolism and development with their surroundings, thereby …

Background We investigated the mechanisms of anti-Candida action of isoquinoline alkaloid
berberine, active constituent of medically important plants of Barberry species. Methods The …

The yeast Snf1/AMP-activated kinase (AMPK) maintains energy homeostasis, controlling
metabolic processes and glucose derepression in response to nutrient levels and …