The genetic epidemiology of substance use disorder: A review

EC Prom-Wormley, J Ebejer, DM Dick… - Drug and alcohol …, 2017 - Elsevier
Background Substance use disorder (SUD) remains a significant public health issue. A
greater understanding of how genes and environment interact to regulate phenotypes …

Emerging role of epigenetic mechanisms in alcohol addiction

TDM Berkel, SC Pandey - Alcoholism: Clinical and …, 2017 - Wiley Online Library
Alcohol use disorder (AUD) is a complex brain disorder with an array of persistent
behavioral and neurochemical manifestations. Both genetic and environmental factors are …

Epigenetics of alcohol use disorder—A review of recent advances in DNA methylation profiling

MJ Longley, J Lee, J Jung, FW Lohoff - Addiction biology, 2021 - Wiley Online Library
Alcohol use disorder (AUD) is a major contributor to morbidity and mortality worldwide.
Although there is a heritable component, the etiology of AUD is complex and can involve …

Current and future prospects for epigenetic biomarkers of substance use disorders

AM Andersen, MV Dogan, SRH Beach, RA Philibert - Genes, 2015 - mdpi.com
Substance abuse has an enormous impact on economic and quality of life measures
throughout the world. In more developed countries, overutilization of the most common forms …

[HTML][HTML] Forensic DNA methylation profiling from evidence material for investigative leads

HY Lee, SD Lee, KJ Shin - BMB reports, 2016 - ncbi.nlm.nih.gov
DNA methylation is emerging as an attractive marker providing investigative leads to solve
crimes in forensic genetics. The identification of body fluids that utilizes tissue-specific DNA …

The dopamine transporter role in psychiatric phenotypes

A Salatino‐Oliveira, LA Rohde… - American Journal of …, 2018 - Wiley Online Library
The dopamine transporter (DAT) is one of the most relevant and investigated
neurotransmitter transporters. DAT is a plasma membrane protein which plays a …

Children's DAT1 polymorphism moderates the relationship between parents' psychological profiles, children's DAT methylation, and their emotional/behavioral …

S Cimino, L Cerniglia, G Ballarotto, E Marzilli… - International journal of …, 2019 - mdpi.com
Parental psychopathological risk is considered as one of the most crucial features
associated with epigenetic modifications in offspring, which in turn are thought to be related …

DNA methylation and alcohol use disorders: Progress and challenges

H Zhang, J Gelernter - The American journal on addictions, 2017 - Wiley Online Library
Background and Objectives Risk for alcohol use disorders (AUDs) is influenced by gene–
environment interactions. Environmental factors can affect gene expression through …

DNA methylation signatures: Biomarkers of drug and alcohol abuse

D Mahna, S Puri, S Sharma - Mutation Research/Reviews in Mutation …, 2018 - Elsevier
DNA sequence is a powerful tool that can be used for an individual's identification and
investigation of various abnormalities in the genome. However, recent studies have …

Epigenetic Analysis of the Dopamine Transporter Gene DAT1 with a Focus on Personality Traits in Athletes

K Humińska-Lisowska, K Chmielowiec… - International Journal of …, 2023 - mdpi.com
Human phenotypes (traits) are determined by the selective use of a person's unique
genotype (DNA sequence), following exposure to environmental stimuli, such as exercise …