Hypoxia is a persistent physiological feature of many different solid tumors and a key driver
of malignancy, and in recent years, it has been recognized as an important target for cancer …

Objectives Oxaliplatin induces chemobrain in cancer patients/survivors. Nutraceutical
naringin has antioxidant and anti-inflammatory properties with low oral bioavailability. Our …

Insufficient activation of the stimulator of interferon genes (STING) signaling pathway and
profoundly immunosuppressive microenvironment largely limits the effect of cancer …

Immunotherapy is a revolutionary achievement in cancer treatment. However, inadequate
immune cells infiltration in tumor microenvironment (TME) always leads to treatment failure …

Hypoxia is a negative prognostic indicator of solid tumors, which not only changes the
survival state of tumors and increases their invasiveness but also remarkably reduces the …

Hyperbaric oxygen therapy is a relatively safe treatment method that has been used for a
long time in the clinic. It has been proven that it can enhance the sensitivity of radiotherapy …

Cyclic GMP-AMP synthetase (cGAS), recognized as the primary DNA sensor within cells,
possesses the capability to identify foreign DNA molecules along with free DNA fragments …

Background Thin endometrium is considered suboptimal for embryo implantation, leading to
compromised pregnancy rates without effective therapies. While some studies have reported …

Metastatic dissemination from the primary tumor is a complex process that requires crosstalk
between tumor cells and the surrounding milieu and involves the interplay between …

Peritumoral hepatocytes are critical components of the liver cancer microenvironment,
However, the role of peritumoral hepatocytes in the local tumor immune interface and the …