Diagnosis and treatment of extrapulmonary tuberculosis

JY Lee - Tuberculosis and respiratory diseases, 2015 - synapse.koreamed.org
Extrapulmonary tuberculosis (EPTB) constitutes about 20% of all cases of tuberculosis (TB)
in Korea. Diagnosing EPTB remains challenging because clinical samples obtained from …

Xpert® MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance

M Kohli, I Schiller, N Dendukuri… - Cochrane Database …, 2018 - cochranelibrary.com
Background Tuberculosis (TB) is the world's leading infectious cause of death.
Extrapulmonary TB accounts for 15% of TB cases, but the proportion is increasing, and over …

The New Xpert MTB/RIF Ultra: Improving Detection of Mycobacterium tuberculosis and Resistance to Rifampin in an Assay Suitable for Point-of-Care Testing

S Chakravorty, AM Simmons, M Rowneki, H Parmar… - MBio, 2017 - Am Soc Microbiol
ABSTRACT The Xpert MTB/RIF assay (Xpert) is a rapid test for tuberculosis (TB) and
rifampin resistance (RIF-R) suitable for point-of-care testing. However, it has decreased …

Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study

NC Bahr, E Nuwagira, EE Evans… - The Lancet infectious …, 2018 - thelancet.com
Summary Background WHO recommends Xpert MTB/RIF as initial diagnostic testing for
tuberculous meningitis. However, diagnosis remains difficult, with Xpert sensitivity of about …

Prevalence of tuberculosis in post-mortem studies of HIV-infected adults and children in resource-limited settings: a systematic review and meta-analysis

RK Gupta, SB Lucas, KL Fielding, SD Lawn - Aids, 2015 - journals.lww.com
Objectives: Tuberculosis (TB) is estimated to be the leading cause of HIV-related deaths
globally. However, since HIV-associated TB frequently remains unascertained, we …

Drug‐resistant tuberculosis: an update on disease burden, diagnosis and treatment

C Lange, D Chesov, J Heyckendorf, CC Leung… - …, 2018 - Wiley Online Library
The emergence of antimicrobial resistance against Mycobacterium tuberculosis, the leading
cause of mortality due to a single microbial pathogen worldwide, represents a growing threat …

Diagnostic biomarkers for active tuberculosis: progress and challenges

BMF Nogueira, S Krishnan… - EMBO Molecular …, 2022 - embopress.org
Tuberculosis (TB) is a leading cause of morbidity and mortality from a single infectious
agent, despite being preventable and curable. Early and accurate diagnosis of active TB is …

Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in children: a systematic review and meta-analysis

AK Detjen, AR DiNardo, J Leyden… - The lancet respiratory …, 2015 - thelancet.com
Background Microbiological confirmation of childhood tuberculosis is rare because of the
difficulty of collection of specimens, low sensitivity of smear microscopy, and poor access to …

Index-TB guidelines: guidelines on extrapulmonary tuberculosis for India

SK Sharma, H Ryan, S Khaparde… - Indian Journal of …, 2017 - journals.lww.com
Extrapulmonary tuberculosis (EPTB) is frequently a diagnostic and therapeutic challenge. It
is a common opportunistic infection in people living with HIV/AIDS and other …

Rapid urine-based screening for tuberculosis in HIV-positive patients admitted to hospital in Africa (STAMP): a pragmatic, multicentre, parallel-group, double-blind …

A Gupta-Wright, EL Corbett, JJ van Oosterhout… - The Lancet, 2018 - thelancet.com
Background Current diagnostics for HIV-associated tuberculosis are suboptimal, with
missed diagnoses contributing to high hospital mortality and approximately 374 000 annual …