The last 40 years have witnessed how p53 rose from a viral binding protein to a central
factor in both stress responses and tumor suppression. The exquisite regulation of p53 …

Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells with defined
factors, hold great promise for regenerative medicine as the renewable source of autologous …

p53 has been studied intensively as a major tumour suppressor that detects oncogenic
events in cancer cells and eliminates them through senescence (a permanent non …

Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function
regulation, play important roles in regulating a variety of cellular physiological and …

The traditional view of p53 activation includes three steps—p53 stabilization, DNA binding,
and transcriptional activation. However, recent studies indicate that each step of p53 …

The p53 tumor suppressor protein has well-established roles in monitoring various types of
stress signals by activating specific transcriptional targets that control cell cycle arrest and …

Mutations in TP53, the gene that encodes the tumour suppressor p53, are found in 50% of
human cancers, and increased levels of its negative regulators MDM2 and MDM4 (also …

O-GlcNAcylation is the covalent attachment of β-DN-acetylglucosamine (GlcNAc) sugars to
serine or threonine residues of nuclear and cytoplasmic proteins, and it is involved in …

Loss of p53 function occurs during the development of most, if not all, tumour types. This
paves the way for genomic instability, tumour-associated changes in metabolism …