The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor
that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the …

Forkhead box transcription factor, FOXM1 is implicated in several cellular processes such as
proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue …

Ubiquitylation and deubiquitylation are reversible protein post-translational modification
(PTM) processes involving the regulation of protein degradation under physiological …

Ubiquitination is an important post-translational modification that can be reversed by a family
of enzymes called deubiquitinating enzymes (DUBs). Ubiquitin-specific protease 28 …

Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes.
However, pathway branches have recently emerged, including Wnt/STOP signaling, which …

The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological
functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is …

FBXW7 (also known as Fbw7, Sel10, hCDC4, or hAgo) is a tumor suppressor and the most
frequently mutated member of the F-box protein family in human cancers. FBXW7 functions …

Circular RNAs (circRNAs) have emerged as crucial regulators of human cancers.
Glutaminolysis supplies cancer cells with adequate nitrogen and carbon to replenish the …

The large family of deubiquitinating enzymes (DUBs) are involved in the regulation of a
plethora of processes carried out inside the cell by protein ubiquitination. Ubiquitination is a …