The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …

Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Elucidating the prefrontal cortical microcircuit has been challenging, given its role in multiple
complex behaviors, including working memory, cognitive flexibility, attention, social …

Social deficit is a core clinical feature of autism spectrum disorder (ASD) but the underlying
neural mechanisms remain largely unclear. We demonstrate that structural and functional …

Interactions between the prefrontal cortex (PFC) and mediodorsal thalamus are critical for
cognitive flexibility, yet the underlying computations are unknown. To investigate …

Interactions between the mediodorsal thalamus and the prefrontal cortex are critical for
cognition. Studies in humans indicate that these interactions may resolve uncertainty in …

Schizophrenia is a chronic disorder characterized by specific positive and negative primary
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …

Fear behavior is under tight control of the prefrontal cortex, but the underlying microcircuit
mechanism remains elusive. In particular, it is unclear how distinct subtypes of inhibitory …

Computational modeling of brain mechanisms of cognition has largely focused on the
cortex, but recent experiments have shown that higher-order nuclei of the thalamus …

Abstract Postsynaptic density protein-95 (PSD-95) is a major regulator in the maturation of
excitatory synapses by interacting and trafficking N-methyl-D-aspartic acid receptors …