Alphaherpesviruses like herpes simplex virus are large DNA viruses characterized by their
ability to establish lifelong latent infection in neurons. As for all herpesviruses …

The order Herpesvirales contains viruses infecting animals from molluscs to men with a
common virion morphology which have been classified into the families Herpesviridae …

ABSTRACT Herpes simplex virus 1 (HSV-1) causes a chronic, lifelong infection in> 60% of
adults. Multiple recent vaccine trials have failed, with viral diversity likely contributing to …

Herpes simplex virus type 1 (HSV-1) is a structurally complex enveloped dsDNA virus that
has evolved to replicate in human neurons and epithelia. Viral gene expression, DNA …

Herpes virions consist of four morphologically distinct structures, a DNA core, capsid,
tegument, and envelope. Tegument occupies the space between the nucleocapsid (capsid …

ABSTRACT Herpes simplex virus 1 (HSV-1) is a well-adapted human pathogen that can
invade the peripheral nervous system and persist there as a lifelong latent infection. Despite …

Morphogenesis and maturation of viral particles is an essential step of viral replication. An
infectious herpesviral particle has a multilayered architecture, and contains a large DNA …

ABSTRACT A distinguishing morphological feature of all herpesviruses is the multiprotein
tegument layer located between the nucleocapsid and lipid envelope of the virion …

Viruses encode for structural proteins that participate in virion formation and include capsid
and envelope proteins. In addition, viruses encode for an array of non-structural accessory …

ABSTRACT Herpes simplex virus 2 (HSV-2) is an important human pathogen that is the
major cause of genital herpes infections and a significant contributor to the epidemic spread …