Ferroptosis: machinery and regulation

X Chen, J Li, R Kang, DJ Klionsky, D Tang - Autophagy, 2021 - Taylor & Francis
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …

Programmed cell death tunes tumor immunity

J Liu, M Hong, Y Li, D Chen, Y Wu, Y Hu - Frontiers in immunology, 2022 - frontiersin.org
The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

Ferroptosis mechanisms involved in neurodegenerative diseases

CO Reichert, FA de Freitas, J Sampaio-Silva… - International journal of …, 2020 - mdpi.com
Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by
the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential …

Oxidative stress: a key modulator in neurodegenerative diseases

A Singh, R Kukreti, L Saso, S Kukreti - Molecules, 2019 - mdpi.com
Oxidative stress is proposed as a regulatory element in ageing and various neurological
disorders. The excess of oxidants causes a reduction of antioxidants, which in turn produce …

Ferroptosis and cancer: mitochondria meet the “iron maiden” cell death

AM Battaglia, R Chirillo, I Aversa, A Sacco, F Costanzo… - Cells, 2020 - mdpi.com
Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …

FTH1 inhibits ferroptosis through ferritinophagy in the 6-OHDA model of Parkinson's disease

Y Tian, J Lu, X Hao, H Li, G Zhang, X Liu, X Li, C Zhao… - …, 2020 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of
dopaminergic neurons associated with dysregulation of iron homeostasis in the brain …

Fighting age-related orthopedic diseases: focusing on ferroptosis

Q Ru, Y Li, W Xie, Y Ding, L Chen, G Xu, Y Wu… - Bone research, 2023 - nature.com
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …

[HTML][HTML] Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging

C Simioni, G Zauli, AM Martelli, M Vitale, G Sacchetti… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is
nowadays seen as an indispensable element for good health, able to lower the risk of …

Ferroptosis and its role in diverse brain diseases

A Weiland, Y Wang, W Wu, X Lan, X Han, Q Li… - Molecular …, 2019 - Springer
Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is
characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads …

Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway

S Wei, T Qiu, X Yao, N Wang, L Jiang, X Jia… - Journal of hazardous …, 2020 - Elsevier
Chronic arsenic exposure is a significantly risk factor for pancreatic dysfunction and type 2
diabetes (T2D). Ferroptosis is a newly identified iron-dependent form of oxidative cell death …