The growth of blood vessels (a process known as angiogenesis) is essential for organ
growth and repair. An imbalance in this process contributes to numerous malignant …

Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls
embryonic development and is also involved in numerous life-threatening human diseases …

The angiopoietin (Ang)–Tie ligand–receptor system has a key regulatory role in regulating
vascular integrity and quiescence. Besides its role in angiogenesis, it is an important …

Psoriasis pathogenesis is closely associated with disease‐inducing Th1 and Th17 cells. Yet,
several studies suggest that aberrant keratinocyte or endothelial cell signalling significantly …

Abstract IL-1F6, IL-1F8, and IL-1F9 and the IL-1R6 (RP2) receptor antagonist IL-1F5
constitute a novel IL-1 signaling system that is poorly characterized in skin. To further …

Psoriasis is a T-cell-mediated chronic inflammatory skin disease believed to be of
autoimmune nature that can be triggered or worsened by streptococcal throat infections. In …

Angiopoietins are ligands of the Tie2 receptor that control angiogenic remodeling in a
context-dependent manner. Tie signaling is involved in multiple steps of the angiogenic …

Psoriasis is a common inflammatory skin disease of unknown etiology, for which there is no
cure. This heterogeneous, cutaneous, inflammatory disorder is clinically characterized by …

Research into the pathophysiology of psoriasis remains challenging, because this disease
does not occur naturally in laboratory animals. However, specific aspects of its complex …

Investigations into the cause and treatment of psoriasis remain at the forefront of basic and
applied clinical research efforts around the world. The purpose for this review is to provide …