The blood–brain barrier (BBB) is the neurovascular structure that regulates the passage of
cells and molecules to and from the central nervous system (CNS). Alzheimer's disease (AD) …

The blood-brain barrier (BBB) is a critical interface separating the central nervous system
from the peripheral circulation, ensuring brain homeostasis and function. Recent research …

The efflux transporter P-glycoprotein (P-gp) at the blood-brain barrier limits the cerebral
uptake of various xenobiotics. To assess the sensitivity of [11C] metoclopramide to measure …

Adenosine triphosphate binding cassette (ABC) transporters are a broad family of
membrane protein complexes that use energy to transport molecules across cells and/or …

[11C] metoclopramide PET imaging provides a sensitive and translational tool to explore P-
glycoprotein (P-gp) function at the blood-brain barrier (BBB). Patients with neurological …

Abstract Organic Anion-Transporting Polypeptides (OATPs) are known to control the liver
uptake of many drugs. Non-hepatic expression of OATPs has been reported although …

Glioma is the most common type of cancer in the central nervous system. Conventional
histopathological classification falls short in capturing the complete pathological spectrum of …

The choice of a reconstruction algorithm in PET affects the accuracy of quantitative
measurements and image interpretation. This study aimed to evaluate the effects of …

Abstract Introduction-The Blood-Brain Barrier P-glycoprotein (P-gp) function can be altered
in several neurodegenerative diseases and due to the administration of different drugs …