[HTML][HTML] Mechanobiology of muscle and myofibril morphogenesis

NM Luis, F Schnorrer - Cells & Development, 2021 - Elsevier
Muscles generate forces for animal locomotion. The contractile apparatus of muscles is the
sarcomere, a highly regular array of large actin and myosin filaments linked by gigantic titin …

Stiffness anisotropy coordinates supracellular contractility driving long-range myotube-ECM alignment

NP Skillin, BE Kirkpatrick, KM Herbert, BR Nelson… - Science …, 2024 - science.org
The ability of cells to organize into tissues with proper structure and function requires the
effective coordination of proliferation, migration, polarization, and differentiation across …

[HTML][HTML] Efficient generation of a self-organizing neuromuscular junction model from human pluripotent stem cells

A Urzi, I Lahmann, LVN Nguyen, BR Rost… - Nature …, 2023 - nature.com
The complex neuromuscular network that controls body movements is the target of severe
diseases that result in paralysis and death. Here, we report the development of a robust and …

Three-dimensional imaging studies in mice identify cellular dynamics of skeletal muscle regeneration

BC Collins, JB Shapiro, MM Scheib, RV Musci… - Developmental Cell, 2024 - cell.com
The function of many organs, including skeletal muscle, depends on their three-dimensional
structure. Muscle regeneration therefore requires not only reestablishment of myofibers but …

Functional specialisation and coordination of myonuclei

A Korb, S Tajbakhsh, GE Comai - Biological Reviews, 2024 - Wiley Online Library
Myofibres serve as the functional unit for locomotion, with the sarcomere as fundamental
subunit. Running the entire length of this structure are hundreds of myonuclei, located at the …

Fibroblast growth factor 8b (FGF-8b) enhances myogenesis and inhibits adipogenesis in rotator cuff muscle cell populations in vitro

T Otsuka, HM Kan, PY Mengsteab… - Proceedings of the …, 2024 - National Acad Sciences
Fatty expansion is one of the features of muscle degeneration due to muscle injuries, and its
presence interferes with muscle regeneration. Specifically, poor clinical outcomes have …

Cellular dynamics of skeletal muscle regeneration

BC Collins, JB Shapiro, MM Scheib, RV Musci… - bioRxiv, 2023 - biorxiv.org
The function of many organs, including skeletal muscle, depends on its three-dimensional
structure. Muscle regeneration therefore requires not only reestablishment of myofibers, but …

Theory of sarcomere assembly inferred from sequential ordering of myofibril components

F Kolley, C Sidor, B Dehapiot, F Schnorrer… - bioRxiv, 2023 - biorxiv.org
Myofibrils in striated muscle cells are chains of regular cytoskeletal units termed sarcomeres,
whose contractions drive voluntary movements of animals. Despite the well characterized …

Mechanisms of Sarcomere Assembly in Muscle Cells Inferred from Sequential Ordering of Myofibril Components

F Kolley, C Sidor, B Dehapiot, F Schnorrer… - PRX Life, 2024 - APS
Voluntary movement in animals is driven by the contraction of myofibrils in striated muscle
cells, which are linear chains of regular cytoskeletal units termed sarcomeres. While the …

[HTML][HTML] Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation

X Chen, Y Li, J Xu, Y Cui, Q Wu, H Yin, Y Li, C Gao… - Elife, 2024 - elifesciences.org
Styxl2, a poorly characterized pseudophosphatase, was identified as a transcriptional target
of the Jak1-Stat1 pathway during myoblast differentiation in culture. Styxl2 is specifically …