The recently-defined four molecular subgroups of medulloblastoma have required updating
of our understanding of in vitro models to include molecular classification and risk …

Tumour cells release an abundance of microvesicles containing a selected set of proteins
and RNAs. Here, we show that tumour microvesicles also carry DNA, which reflects the …

The molecular classification of medulloblastoma: driving the... : Current Opinion in Pediatrics
The molecular classification of medulloblastoma: driving the next generation clinical trials …

Several molecular and histopathological prognostic markers have been proposed for the
therapeutic stratification of medulloblastoma patients. Amplification of the c-myc oncogene …

Medulloblastoma (MB) is a childhood malignant brain tumour comprising four main
subgroups characterized by different genetic alterations and rate of mortality. Among MB …

Abstract c‐Myc dysregulation is one of the most common abnormalities found in human
cancer. MicroRNAs (miRNAs) are functionally intertwined with the c‐Myc network as multiple …

Object Malignant brain tumors have been proved to be resistant to standard treatments and
therefore require new therapeutic strategies. Survivin, a recently described member of the …

Purpose: To identify better risk stratification systems in childhood medulloblastoma based on
clinical factors and analysis of routinely processed formalin-fixed tumor material …

To better understand the genetic basis of medulloblastoma development, we sought
genomic amplifications and deletions in these tumors using digital karyotyping in …

Medulloblastoma (MB) is the most common malignant brain tumor of childhood. Current
therapies are toxic and not always curative that necessitates development of targeted …