[HTML][HTML] Deep learning facilitates multi-data type analysis and predictive biomarker discovery in cancer precision medicine

VB Mathema, P Sen, S Lamichhane, M Orešič… - Computational and …, 2023 - Elsevier
Cancer progression is linked to gene-environment interactions that alter cellular
homeostasis. The use of biomarkers as early indicators of disease manifestation and …

Towards a safe and efficient clinical implementation of machine learning in radiation oncology by exploring model interpretability, explainability and data-model …

A Barragán-Montero, A Bibal… - Physics in Medicine …, 2022 - iopscience.iop.org
The interest in machine learning (ML) has grown tremendously in recent years, partly due to
the performance leap that occurred with new techniques of deep learning, convolutional …

Brain tumor classification using a combination of variational autoencoders and generative adversarial networks

B Ahmad, J Sun, Q You, V Palade, Z Mao - Biomedicines, 2022 - mdpi.com
Brain tumors are a pernicious cancer with one of the lowest five-year survival rates.
Neurologists often use magnetic resonance imaging (MRI) to diagnose the type of brain …

Reinforcement learning for precision oncology

JN Eckardt, K Wendt, M Bornhaeuser, JM Middeke - Cancers, 2021 - mdpi.com
Simple Summary The accelerating merger of information technology and cancer research
heralds the advent of novel methods and models for clinical decision making in oncology …

Computational approaches to modelling and optimizing cancer treatment

TO McDonald, YC Cheng, C Graser, PB Nicol… - Nature Reviews …, 2023 - nature.com
Computational models can be applied to optimize treatment schedules and model treatment
responses in cancer therapy. In this Review, we provide an overview of such computational …

Current status and future developments in predicting outcomes in radiation oncology

D Niraula, S Cui, J Pakela, L Wei, Y Luo… - The British Journal of …, 2022 - academic.oup.com
Advancements in data-driven technologies and the inclusion of information-rich multiomics
features have significantly improved the performance of outcomes modeling in radiation …

Optimization of antitumor radiotherapy fractionation via mathematical modeling with account of 4 R's of radiobiology

M Kuznetsov, A Kolobov - Journal of Theoretical Biology, 2023 - Elsevier
A spatially-distributed continuous mathematical model of solid tumor growth and treatment
by fractionated radiotherapy is presented. The model explicitly accounts for the factors …

Deep learning for reaction-diffusion glioma growth modeling: Towards a fully personalized model?

C Martens, A Rovai, D Bonatto, T Metens, O Debeir… - Cancers, 2022 - mdpi.com
Simple Summary Mathematical tumor growth models have been proposed for decades to
capture the growth of gliomas, an aggressive form of brain tumor. However, the estimation of …

Medical Knowledge Integration into Reinforcement Learning Algorithms for Dynamic Treatment Regimes

S Yazzourh, N Savy, P Saint-Pierre… - arXiv preprint arXiv …, 2024 - arxiv.org
The goal of precision medicine is to provide individualized treatment at each stage of
chronic diseases, a concept formalized by Dynamic Treatment Regimes (DTR). These …

New Insights in Radiotherapy

C Martínez-Campa - Biomedicines, 2022 - mdpi.com
This Special Issue of Biomedicines, entitled “New insights in Radiotherapy”, compiles
insightful reviews on the state of the art on different aspects of radiation therapy, and also …