The most advanced in vitro cardiac models are today based on the use of induced
pluripotent stem cells (iPSCs); however, the maturation of cardiomyocytes (CMs) has not yet …

Microphysiological systems (MPS) are drawing increasing interest from academia and from
biomedical industry due to their improved capability to capture human physiology. MPS offer …

Organ-on-a-chip (OOC) is a new type of biochip technology. Various types of OOC systems
have been developed rapidly in the past decade and found important applications in drug …

Three dimensional (3D) scaffolds have huge limitations due to their low porosity, mechanical
strength, and lack of direct cell‐bioactive drug contact. Whereas bisphosphonate drug has …

Increasing evidence has accumulated that gut microbiome dysbiosis could be linked to
neurological diseases, including both neurodegenerative and psychiatric diseases. With the …

Exposure to micro-and nanoplastics (MNPs) has been implicated in potential cardiotoxicity.
However, in vitro models based on cardiomyocyte cell lines lack crucial cardiac …

Cardiomyocyte (CM) maturation is the transformation of differentiated fetal CMs into adult
CMs that involves changes in morphology, cell function and metabolism, and the …

The fabrication of 3D bioconstructs using bioprinters will advance the field of regenerative
medicine owing to its ability to facilitate clinical treatments. Additional stimulations have …

Cardiovascular disease is a globally prevalent disease with far-reaching medical and socio-
economic consequences. Although improvements in treatment pathways and …

Congenital heart disease (CHD) is the most predominant birth defect and can require
several invasive surgeries throughout childhood. The absence of materials with growth and …