Chronic myeloid leukemia (CML) is probably the most extensively studied human
malignancy. The discovery of the Philadelphia (Ph) chromosome in 19601 as the first …

Aberrant tyrosine kinase activity plays a critical role in many hematologic disorders,
including chronic myeloid leukemia characterized by the constitutive activity of BCR-ABL …

The oncogenic BCR/ABL kinase activity induces and maintains chronic myelogenous
leukemia (CML). We show here that, in BCR/ABL-transformed cells and CML blast crisis …

Mitogen-activated protein (Map) kinases are widely expressed serine-threonine kinases that
mediate important regulatory signals in the cell. Three major groups of Map kinases exist …

Part of the cellular response to toxins, physical stresses and inflammatory cytokines occurs
by signalling via the stress-activated protein kinase (SAPK) and p38 reactivating kinase …

The twenty-first century is beginning with a sharp turn in the field of cancer therapy.
Molecular targeted therapies against specific oncogenic events are now possible. The BCR …

Constitutively activating internal tandem duplication (ITD) and point mutations of the receptor
tyrosine kinase FLT3 are present in up to 41% of patients with acute myeloid leukemia …

Blast crisis chronic myelogenous leukemia (CML-BC) and Philadelphia chromosome–
positive (Ph1-positive) acute lymphocytic leukemia (ALL) are 2 fatal BCR/ABL-driven …

Bcr–Abl is a chimeric oncoprotein that is strongly implicated in acute lymphoblastic (ALL)
and chronic myelogenous leukemias (CML). This deregulated tyrosine kinase selectively …

Philadelphia (Ph*)/BCR-ABL1-positive chronic myeloid leukemia (CML) is a neoplastic
hematologic disorder, which is a functionally curable chronic disease via using tyrosine …