Synthetic cells: From simple bio‐inspired modules to sophisticated integrated systems

C Guindani, LC da Silva, S Cao, T Ivanov… - Angewandte …, 2022 - Wiley Online Library
Bottom‐up synthetic biology is the science of building systems that mimic the structure and
function of living cells from scratch. To do this, researchers combine tools from chemistry …

[HTML][HTML] Chemical communication at the synthetic cell/living cell interface

V Mukwaya, S Mann, H Dou - Communications Chemistry, 2021 - nature.com
Although the complexity of synthetic cells has continued to increase in recent years,
chemical communication between protocell models and living organisms remains a key …

Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells

S Liu, Y Zhang, M Li, L Xiong, Z Zhang, X Yang… - Nature Chemistry, 2020 - nature.com
The design and construction of synthetic therapeutic protocells capable of establishing
cognate chemical communication channels with living cells is an important challenge for …

[HTML][HTML] Intercellular communication between artificial cells by allosteric amplification of a molecular signal

BC Buddingh', J Elzinga, JCM van Hest - Nature communications, 2020 - nature.com
Multicellular organisms rely on intercellular communication to coordinate the behaviour of
individual cells, which enables their differentiation and hierarchical organization. Various …

Interfacing living and synthetic cells as an emerging frontier in synthetic biology

Y Elani - Angewandte Chemie, 2021 - Wiley Online Library
The construction of artificial cells from inanimate molecular building blocks is one of the
grand challenges of our time. In addition to being used as simplified cell models to decipher …

[HTML][HTML] Communication and quorum sensing in non-living mimics of eukaryotic cells

H Niederholtmeyer, C Chaggan, NK Devaraj - Nature communications, 2018 - nature.com
Cells in tissues or biofilms communicate with one another through chemical and mechanical
signals to coordinate collective behaviors. Non-living cell mimics provide simplified models …

Compartmentalizing cell-free systems: toward creating life-like artificial cells and beyond

E Cho, Y Lu - ACS Synthetic Biology, 2020 - ACS Publications
Building an artificial cell is a research area that is rigorously studied in the field of synthetic
biology. It has brought about much attention with the aim of ultimately constructing a natural …

Programmed assembly of synthetic protocells into thermoresponsive prototissues

P Gobbo, AJ Patil, M Li, R Harniman, WH Briscoe… - Nature materials, 2018 - nature.com
Although several new types of synthetic cell-like entities are now available, their structural
integration into spatially interlinked prototissues that communicate and display coordinated …

Microfluidics for biosynthesizing: from droplets and vesicles to artificial cells

Y Ai, R Xie, J Xiong, Q Liang - Small, 2020 - Wiley Online Library
Fabrication of artificial biomimetic materials has attracted abundant attention. As one of the
subcategories of biomimetic materials, artificial cells are highly significant for multiple …

The all-E. coliTXTL toolbox 3.0: new capabilities of a cell-free synthetic biology platform

D Garenne, S Thompson, A Brisson… - Synthetic …, 2021 - academic.oup.com
The new generation of cell-free gene expression systems enables the prototyping and
engineering of biological systems in vitro over a remarkable scope of applications and …