We describe the development and potential use of various designs of recombinant HIV‐1
envelope glycoprotein trimers that mimic the structure of the virion‐associated spike, which …

▪ Abstract Viral envelope glycoproteins promote viral infection by mediating the fusion of the
viral membrane with the host-cell membrane. Structural and biochemical studies of two viral …

The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …

Recombinant trimeric mimics of the human immunodeficiency virus type 1 (HIV-1) envelope
glycoprotein (Env) spike should expose as many epitopes as possible for broadly …

Interaction with the CD4 receptor enhances the exposure on the human immunodeficiency
type 1 gp120 exterior envelope glycoprotein of conserved, conformation-dependent …

This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …

Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1
(HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect …

The third variable (V3) domain has been implicated in determining the human
immunodeficiency virus (HIV) phenotype, including fusion capacity and monocytotropism. In …

The CCR5 co-receptor binds to the HIV-1 gp120 envelope glycoprotein and facilitates HIV-1
entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the …

Previous experiments indicate that the V3 hypervariable region of the human
immunodeficiency virus (HIV) envelope protein influences cell tropism of infection; however …