Plant antimicrobial peptides (AMPs) have evolved differently from AMPs from other life
forms. They are generally rich in cysteine residues which form multiple disulfides. In turn, the …

This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

Chronic pain is a universal health issue associated with numerous medical conditions, for
example after severe burns or following major surgery.[1] Compelling evidence suggests …

This review article presents important and recent progress in the manufacture and
application of antimicrobial macromolecules. Microbial infections continue to endanger …

Cyclotides are globular microproteins with a unique head‐to‐tail cyclized backbone,
stabilized by three disulfide bonds forming a cystine knot. This unique circular backbone …

Cyclotides are a novel class of micro-proteins (≈ 30–40 residues long) with a unique
topology containing a head-to-tail cyclized backbone structure further stabilized by three …

Cyclotides are a family of plant peptides characterized by a cystine knot embedded in a
macrocyclic backbone. They bind to and disrupt phospholipid membranes, which explain …

Disulfides in peptides and proteins are essential for maintaining a properly folded structure.
Their oxidative folding is invariably performed in an aqueous‐buffered solution. However …

This review provides an overview of the properties of cyclotides and their potential for
developing novel peptide-based therapeutics. The selective disruption of protein–protein …