Deep brain stimulation (DBS) is an established procedure for the symptomatic treatment of
Parkinson's disease. Several deep brain nuclei have been stimulated, producing a wide …

Pedunculopontine nucleus region deep brain stimulation (DBS) is a promising but
experimental therapy for axial motor deficits in Parkinson's disease (PD), particularly gait …

Deep brain stimulation of the subthalamic nucleus is an effective and established therapy for
patients with advanced Parkinson's disease improving quality of life, motor symptoms and …

Sleep disturbances are among the most common nonmotor complications of Parkinson's
disease (PD), can present in prodromal stages, and progress with advancing disease. In …

The neurosurgical treatment of movement disorders, primarily via deep brain stimulation
(DBS), is a rapidly expanding and evolving field. Although conventional targets including the …

In patients with Parkinson's disease, gait and balance difficulties have emerged as some of
the main therapeutic concerns. During earlier stages of the disease, the dopamine …

Background: The objective of this study was to investigate 24‐month of effects of bilateral
subthalamic nucleus (STN) deep brain stimulation (DBS) on nonmotor symptoms in …

We present data from animal studies showing that the pedunculopontine tegmental nucleus—
conserved through evolution, compartmentalized, and with a complex pattern of inputs and …

Background: Although the diagnosis of Parkinson disease (PD) still relies mainly on the
appearance of its classical motor features of resting tremor, rigidity, bradykinesia, and …

Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common
neurodegenerative disorders and exact a burden on our society greater than cardiovascular …