Epigenetics and epigenomics in diabetic kidney disease and metabolic memory
M Kato, R Natarajan - Nature Reviews Nephrology, 2019 - nature.com
The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …
complication of diabetes mellitus, are influenced by both genetic and environmental factors …
[HTML][HTML] Treatment of diabetic kidney disease: current and future
T Yamazaki, I Mimura, T Tanaka… - Diabetes & metabolism …, 2021 - ncbi.nlm.nih.gov
Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease. However,
only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD …
only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD …
Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression
The proximal tubule is a key regulator of kidney function and glucose metabolism. Diabetic
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease
T Yang, EM Richards, CJ Pepine… - Nature Reviews …, 2018 - nature.com
Crosstalk between the gut microbiota and the host has attracted considerable attention
owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly …
owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly …
Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling
Background In recent years the Illumina HumanMethylation450 (HM450) BeadChip has
provided a user-friendly platform to profile DNA methylation in human samples. However …
provided a user-friendly platform to profile DNA methylation in human samples. However …
Kidney fibrosis: from mechanisms to therapeutic medicines
R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …
Diabetic kidney disease
The kidney is arguably the most important target of microvascular damage in diabetes. A
substantial proportion of individuals with diabetes will develop kidney disease owing to their …
substantial proportion of individuals with diabetes will develop kidney disease owing to their …
Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development
Renal fibrosis is the histological manifestation of a progressive, usually irreversible process
causing chronic and end-stage kidney disease. We performed genome-wide transcriptome …
causing chronic and end-stage kidney disease. We performed genome-wide transcriptome …
Molecular mechanisms of diabetic kidney disease
K Reidy, HM Kang, T Hostetter… - The Journal of clinical …, 2014 - Am Soc Clin Investig
Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide and the
single strongest predictor of mortality in patients with diabetes. DKD is a prototypical disease …
single strongest predictor of mortality in patients with diabetes. DKD is a prototypical disease …
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …