Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs)
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …

Bromodomain and extraterminal (BET) proteins bind acetylated lysine residues in histones
and nonhistone proteins via tandem bromodomains and regulate chromatin dynamics …

Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality.
Causes are ill defined but could be through direct cardiac infection and/or inflammation …

Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal
mutations remains challenging. We hypothesized that genetic determinants for CHDs may …

Higher-order chromatin structure regulates gene expression, and mutations in proteins
mediating genome folding underlie developmental disorders known as cohesinopathies …

Chronic inflammation and tissue fibrosis are common responses that worsen organ function,
yet the molecular mechanisms governing their cross-talk are poorly understood. In diseased …

Reprogramming lipid metabolism is considered a fundamental step in tumourigenesis that
influences ferroptosis. However, molecular mechanisms between lipid metabolism and …

Under subarachnoid hemorrhage (SAH) conditions, astrocytes undergo a marked
intensification of glycolytic activity, resulting in the generation of substantial amounts of …

Diabetic cardiomyopathy (DCM) is defined as the presence in diabetic patients of abnormal
cardiac structure and performance (such as left ventricular hypertrophy, fibrosis, and …

Background Aging, a complex and profound journey, leads us through a labyrinth of
physiological and pathological transformations, rendering us increasingly susceptible to …