Diabetes mellitus is characterized by the failure of insulin-secreting pancreatic β-cells (or β-
cell death) due to either autoimmunity (type 1 diabetes mellitus) or failure to compensate for …

Relevant reviews highlight the association between dysfunctional mitochondria and
inflammation, but few studies address the contribution of mitochondria and mitochondria …

The central metabolic regulator SnRK1 controls plant growth and survival upon activation by
energy depletion, but detailed molecular insight into its regulation and downstream targets is …

Glycosylation of immune receptors and ligands, such as T cell receptor and coinhibitory
molecules, regulates immune signaling activation and immune surveillance. However, how …

The concentration of Ca 2+ in the endoplasmic reticulum (ER) is critically important for
maintaining its oxidizing environment as well as for maintaining luminal ATP levels required …

Solute carriers (SLCs) are the largest family of transmembrane transporters in humans and
are major determinants of cellular metabolism. Several SLCs have been shown to be …

The past decade has seen the emergence of endoplasmic reticulum (ER) chaperones as
key determinants of contact formation between mitochondria and the ER on the …

Inside cells, the endoplasmic reticulum (ER) forms the largest Ca 2+ store. Ca 2+ is actively
pumped by the SERCA pumps in the ER, where intraluminal Ca 2+-binding proteins enable …

Accumulated unfolded proteins in the endoplasmic reticulum (ER) trigger the unfolded
protein response (UPR) to increase ER protein folding capacity. ER proteostasis and UPR …

The covalent attachment of sugars to growing glycan chains is heavily reliant on a specific
family of solute transporters (SLC35), the nucleotide sugar transporters (NSTs) that connect …