1.1. Brief Historical Overview As expected from the fluorine position on the periodic table of
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …

The increasing recognition of cyclic vomiting syndrome (CVS) in adults prompted the
development of these evidence‐based guidelines on the management of CVS in adults …

Background Chemotherapy-induced nausea and vomiting (CINV) in cancer patients are
common symptoms most feared by patients. The aim of this study was to analyze the impact …

Recent research has investigated the expression and secretion of neuropeptides by tumors,
and the potential of these peptides to facilitate tumor growth and spread. In particular …

Background Cyclic vomiting syndrome (CVS) and cannabinoid hyperemesis syndrome
(CHS) are both characterized by episodic, acute transitions from asymptomatic states to …

The prevention of chemotherapy‐induced nausea and vomiting was one of the most
challenging supportive care issues in oncology, especially to highly emetogenic …

In recent years, chemotherapy-induced nausea and vomiting (CINV) has become the most
common adverse effect of chemotherapy in oncology patients. The CINV may reduce the …

Emend, an NK1 antagonist, and dexamethasone are used to treat complications associated
with metastatic brain tumours and their treatment. It has been suggested that these agents …

Chemotherapy-induced nausea and vomiting (CINV) and radiotherapy-induced nausea and
vomiting (RINV) strongly affect the quality of life of patients with cancer. Inadequate …

This chapter focuses on the various prodrug approaches that have been used to overcome
many of the pharmaceutical and pharmacokinetic barriers that hinder the optimal delivery of …