Sepsis is a common clinical entity causing thousands of deaths and costing billions of
healthcare dollars annually in the US alone [1–4]. Further, sepsis and septic shock represent …

The common view is that T lymphocytes activate telomerase to delay senescence. Here we
show that some T cells (primarily naïve and central memory cells) elongated telomeres by …

Preclinical animal studies are mandatory before new treatments can be tested in clinical
trials. However, their use in developing new therapies for sepsis has been controversial …

Background The lack of a reliable scoring system that predicts the development of septic
shock and death precludes comparison of disease and/or treatment outcomes in animal …

The lung naturally resists Aspergillus fumigatus (Af) in healthy individuals, but multiple
conditions can disrupt this resistance, leading to lethal invasive infections. Core processes …

Abstract Background Neutrophil extracellular traps (NETs) facilitate bacterial clearance but
also promote thrombosis and organ injury in sepsis. We quantified ex vivo NET induction in …

Methods: Wild-type, PCSK9 knockout (KO), and transgenic (Tg) mice that overexpress
PCSK9 were subjected to sham surgery or cecal ligation and puncture (CLP). Bacterial …

Background Despite increasing ethical standards for conducting animal research, death is
still often used as an endpoint in mouse sepsis studies. Recently, the Murine Sepsis Score …

Severe sepsis induces a sustained immune dysfunction associated with poor clinical
behavior. In particular, lymphopenia along with increased lymphocyte apoptosis and …

The emergence and ensuing dominance of COVID-19 on the world stage has emphasized
the urgency of efficient animal models for the development of therapeutics for and …