PK/PD modelling of glucose-insulin-glucagon dynamics in healthy dogs after a subcutaneous bolus administration of native glucagon or a novel glucagon analogue

SL Wendt, JK Møller, CB Knudsen, H Madsen… - 2016 - orbit.dtu.dk
Objective We aim to develop a simulation model of the complex glucose-insulin-glucagon
dynamics based on physiology and data. Furthermore, we compare pharmacokinetic (PK) …

Bihormonal glucose control using a continuous insulin pump and a glucagon-pen

M Reiter, F Reiterer, L del Re - 2016 European Control …, 2016 - ieeexplore.ieee.org
The combined use of insulin and glucagon in the diabetes therapy has been proposed as a
robust alternative to the classical insulin only approach relieving the patient of the …

[PDF][PDF] Glucagon administration strategies for a dual-hormone artificial pancreas

V Bátora, D Boiroux, M Hagdrup, M Tárnık… - IEEE Transactions on …, 2015 - imm.dtu.dk
In this paper, we describe and evaluate Model Predictive Control (MPC) algorithms for an
Artificial Pancreas (AP) with both insulin and glucagon. Such a device is called a dual …

[PDF][PDF] Investigation of glucagon administration methods in a bihormonal artificial pancreas/eingereicht von: Matthias Reiter

M Reiter - 2015 - epub.jku.at
Since diabetes is a disease of huge global impact, great effort has been made to develop
therapies that allow an unburdened and healthy life. One of those is the insulin therapy …