Crossing the bridge: large animal models in translational transplantation research
AD Kirk - Immunological reviews, 2003 - Wiley Online Library
Many methods for reducing the immunosuppressive requirements of allotransplantation
have been proposed based on a growing understanding of physiological and allospecific …
have been proposed based on a growing understanding of physiological and allospecific …
[HTML][HTML] The inhibition of CD40/CD154 costimulatory signaling in the prevention of renal transplant rejection in nonhuman primates: A systematic review and meta …
S Perrin, M Magill - Frontiers in Immunology, 2022 - frontiersin.org
The prevention of allograft transplant rejection by inhibition of the CD40/CD40L
costimulatory pathway has been described in several species. We searched pubmed for …
costimulatory pathway has been described in several species. We searched pubmed for …
The anti-CD40L monoclonal antibody AT-1501 promotes islet and kidney allograft survival and function in nonhuman primates
Prior studies of anti-CD40 ligand (CD40L)–based immunosuppression demonstrated
effective prevention of islet and kidney allograft rejection in nonhuman primate models; …
effective prevention of islet and kidney allograft rejection in nonhuman primate models; …
[HTML][HTML] Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154
CD154 is a cell surface molecule expressed on activated T cells that binds to CD40, an
activating molecule on APCs. Its blockade has been shown to prevent allograft rejection …
activating molecule on APCs. Its blockade has been shown to prevent allograft rejection …
Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation1
W Schuler, M Bigaud, V Brinkmann, F Di Padova… - …, 2004 - journals.lww.com
Background. Anti-CD154 monoclonal antibodies (mAbs) cause long-term graft survival in
preclinical allotransplantation experiments. This is the first report on the efficacy and safety …
preclinical allotransplantation experiments. This is the first report on the efficacy and safety …
Monotherapy with the novel human anti-CD154 monoclonal antibody ABI793 in rhesus monkey renal transplantation model1
Background. This study assesses the safety and efficacy of the novel human anti-human
CD154 monoclonal antibody ABI793 in rhesus monkeys. Methods. Outbred rhesus monkeys …
CD154 monoclonal antibody ABI793 in rhesus monkeys. Methods. Outbred rhesus monkeys …
[HTML][HTML] Transplant tolerance in non-human primates: progress, current challenges and unmet needs
LS Kean, S Gangappa, TC Pearson… - American journal of …, 2006 - Elsevier
Given the significant morbidity associated with current post-transplant immunosuppressive
regimens, induction of immune tolerance continues to be an important goal of clinical organ …
regimens, induction of immune tolerance continues to be an important goal of clinical organ …
Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin …
H Xu, SP Montgomery, EH Preston… - The Journal of …, 2003 - journals.aai.org
Anti-CD154 variably prolongs allograft survival in nonhuman primates. Rodent studies
suggest that adding pretransplant donor-specific transfusion (DST) and/or rapamycin to anti …
suggest that adding pretransplant donor-specific transfusion (DST) and/or rapamycin to anti …
Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation
SP Montgomery, H Xu, DK Tadaki, A Celniker… - …, 2002 - journals.lww.com
Background. Antibodies and fusion proteins specific for CD80, CD86, and CD154 have
shown promise as agents capable of inducing donor-specific tolerance in rodents. These …
shown promise as agents capable of inducing donor-specific tolerance in rodents. These …
Primate models in organ transplantation
DJ Anderson, AD Kirk - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Large animal models have long served as the proving grounds for advances in
transplantation, bridging the gap between inbred mouse experimentation and human …
transplantation, bridging the gap between inbred mouse experimentation and human …