Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

Hydroxyapatite (HAp) has significant biological activity, degradability, and osteoconductivity.
In recent decades, it has been widely used in dentistry, anti-tumour drug carriers, and …

Calcium phosphate (CaP) bioceramics are widely used in the field of bone regeneration,
both in orthopedics and in dentistry, due to their good biocompatibility, osseointegration and …

The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

Biomedical implants have been widely used in various orthopedic treatments, including total
hip arthroplasty, joint arthrodesis, fracture fixation, non-union, dental repair, etc. The modern …

Biomineralization is the process by which organisms form mineralized tissues with
hierarchical structures and excellent properties, including the bones and teeth in …

The observation and investigation of phenomena in the natural world can inspire the
discovery of new materials and a greater understanding of the underlying physical …

Bone, as a mineralized composite of inorganic (mostly carbonated hydroxyapatite) and
organic (mainly type I collagen) phases, possesses a unique combination of remarkable …

Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …

Bone tissue is a complex biocomposite material with a variety of organic (eg, proteins, cells)
and inorganic (eg, hydroxyapatite crystals) components hierarchically organized with …