Neutrophil diversity and plasticity in tumour progression and therapy
Neutrophils play a key role in defence against infection and in the activation and regulation
of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have …
of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have …
Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer
SA Jones, BJ Jenkins - Nature reviews immunology, 2018 - nature.com
The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM),
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …
Changes in nutritional status impact immune cell metabolism and function
Y Alwarawrah, K Kiernan, NJ MacIver - Frontiers in immunology, 2018 - frontiersin.org
Immune cell function and metabolism are closely linked. Many studies have now clearly
demonstrated that alterations in cellular metabolism influence immune cell function and that …
demonstrated that alterations in cellular metabolism influence immune cell function and that …
The role of IL-6 in host defence against infections: immunobiology and clinical implications
S Rose-John, K Winthrop, L Calabrese - Nature Reviews Rheumatology, 2017 - nature.com
IL-6 is a pleiotropic cytokine with broad-ranging effects within the integrated immune
response. One of the roles of IL-6 is to support immunocompetence, defined as the ability of …
response. One of the roles of IL-6 is to support immunocompetence, defined as the ability of …
Emergency granulopoiesis
MG Manz, S Boettcher - Nature Reviews Immunology, 2014 - nature.com
Neutrophils are a key cell type of the innate immune system. They are short-lived and need
to be continuously generated in steady-state conditions from haematopoietic stem and …
to be continuously generated in steady-state conditions from haematopoietic stem and …
Tocilizumab for cytokine storm syndrome in COVID-19 pneumonia: an increased risk for candidemia?
S Antinori, C Bonazzetti, G Gubertini, A Capetti… - Autoimmunity …, 2020 - ncbi.nlm.nih.gov
We have read with interest the excellent review by McGonagle et al. discussing the possible
role of hyperinflammation secondary to macrophage activation syndrome (MAS) or cytokine …
role of hyperinflammation secondary to macrophage activation syndrome (MAS) or cytokine …
Interleukin-6 and chronic inflammation
C Gabay - Arthritis research & therapy, 2006 - Springer
Abstract Interleukin (IL)-6 is produced at the site of inflammation and plays a key role in the
acute phase response as defined by a variety of clinical and biological features such as the …
acute phase response as defined by a variety of clinical and biological features such as the …
IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.
IL-6 is induced often together with the proinflammatory cytokines TNFalpha and IL-1 in many
alarm conditions, and circulating IL-6 plays an important role in the induction of acute phase …
alarm conditions, and circulating IL-6 plays an important role in the induction of acute phase …
Regulation of inflammation-and infection-driven hematopoiesis
S Boettcher, MG Manz - Trends in immunology, 2017 - cell.com
Innate myeloid immune cells, and neutrophils in particular, serve as first line of defense
against pathogenic microorganisms including bacteria and fungi. Given their short life span …
against pathogenic microorganisms including bacteria and fungi. Given their short life span …
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
Members of the IL-6 cytokine family are involved in a variety of biological responses,
including the immune response, inflammation, hematopoiesis, and oncogenesis by …
including the immune response, inflammation, hematopoiesis, and oncogenesis by …