The physiology of continuous-flow left ventricular assist devices

HS Lim, N Howell, A Ranasinghe - Journal of cardiac failure, 2017 - Elsevier
The use of left ventricular assist devices (LVADs) has increased significantly over the past
few years, in part because heart transplant activity has plateaued, but also because of the …

Determinants of exercise performance in heart failure patients with extremely reduced cardiac output and left ventricular assist device

A Apostolo, C Vignati, M Cittar… - European Journal of …, 2023 - academic.oup.com
The evaluation of exercise capacity and cardiac output (QC) is fundamental in the
management of patients with advanced heart failure (AdHF). QC and peak oxygen uptake …

Use of a pulmonary artery pressure sensor to manage patients with left ventricular assist devices

V Thohan, J Abraham, A Burdorf… - Circulation: Heart …, 2023 - Am Heart Assoc
Background: Hemodynamic-guided management with a pulmonary artery pressure sensor
(CardioMEMS) is effective in reducing heart failure hospitalization in patients with chronic …

LVAD pump flow does not adequately increase with exercise

C Gross, C Marko, J Mikl, J Altenberger… - Artificial …, 2019 - Wiley Online Library
Left ventricular assist devices (LVADs) restore cardiovascular circulatory demand at rest with
a spontaneous increase in pump flow to exercise. The relevant contribution of cardiac output …

Lvad pump speed increase is associated with increased peak exercise cardiac output and vo2, postponed anaerobic threshold and improved ventilatory efficiency

C Vignati, A Apostolo, G Cattadori, S Farina… - International journal of …, 2017 - Elsevier
Backgrounds Peak exercise cardiac output (CO) increase is associated with an increase of
peak oxygen uptake (VO 2), provided that arteriovenous O 2 difference [Δ (Ca− Cv) O 2] …

Limiting factors of peak and submaximal exercise capacity in LVAD patients

L Fresiello, S Jacobs, P Timmermans, R Buys… - PLoS …, 2020 - journals.plos.org
Aims Although patients supported with a Continuous-Flow Left Ventricular Assist Device (CF-
LVAD) are hemodynamically stable, their exercise capacity is limited. Hence, the aim of this …

Comprehensive effects of left ventricular assist device speed changes on alveolar gas exchange, sleep ventilatory pattern, and exercise performance

A Apostolo, S Paolillo, M Contini, C Vignati… - The Journal of Heart and …, 2018 - Elsevier
BACKGROUND Increasing left ventricular assist device (LVAD) pump speed according to
the patient's activity is a fascinating hypothesis. This study analyzed the short-term effects of …

Left atrial appendage occlusion in ventricular assist device patients to decrease thromboembolic events: A computer simulation study

M Ghodrati-Misek, T Schlöglhofer, C Gross… - Frontiers in …, 2022 - frontiersin.org
Atrial fibrillation (AF) is a common comorbidity in left ventricular assist device (LVAD)
patients and has been identified as a risk factor for thromboembolic stroke. Blood stagnation …

Changes in total cardiac output and oxygen extraction during exercise in patients supported with an HVAD left ventricular assist device

T Schmidt, B Bjarnason‐Wehrens, S Mommertz… - Artificial …, 2018 - Wiley Online Library
Following implantation of a left ventricular assist device (LVAD), acceptable functional
performance is now being achieved; however, peak VO2 and peak work load (watts) remain …

Exercise capacity in ventricular assist device patients: clinical relevance of pump speed and power

L Fresiello, R Buys, P Timmermans… - European Journal of …, 2016 - academic.oup.com
OBJECTIVES Patients with ventricular assist device (VAD) show a limited exercise capacity.
The aim of this work is to investigate whether VAD speed increase has an effect on exercise …