Huntington disease: natural history, biomarkers and prospects for therapeutics
CA Ross, EH Aylward, EJ Wild, DR Langbehn… - Nature Reviews …, 2014 - nature.com
Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …
caused by a single genetic mutation and is amenable to predictive genetic testing, with …
Voxel-based morphometry of the human brain: methods and applications
In recent years, a whole-brain unbiased objective technique, known as voxel-based
morphometry (VBM), has been developed to characterise brain differences in vivo using …
morphometry (VBM), has been developed to characterise brain differences in vivo using …
Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data
SJ Tabrizi, DR Langbehn, BR Leavitt… - The Lancet …, 2009 - thelancet.com
Background Huntington's disease (HD) is an autosomal dominant, fully penetrant,
neurodegenerative disease that most commonly affects adults in mid-life. Our aim was to …
neurodegenerative disease that most commonly affects adults in mid-life. Our aim was to …
Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis
Background TRACK-HD is a prospective observational study of Huntington's disease (HD)
that examines disease progression in premanifest individuals carrying the mutant HTT gene …
that examines disease progression in premanifest individuals carrying the mutant HTT gene …
Where in the brain is depression?
Major depressive disorder is a serious medical illness which is responsible for considerable
morbidity and disability. Despite decades of research, the neural basis for depression is still …
morbidity and disability. Despite decades of research, the neural basis for depression is still …
Detection of Huntington's disease decades before diagnosis: the Predict-HD study
Objective: The objective of the Predict-HD study is to use genetic, neurobiological and
refined clinical markers to understand the early progression of Huntington's disease (HD) …
refined clinical markers to understand the early progression of Huntington's disease (HD) …
Neuroimaging of the periaqueductal gray: state of the field
This review and meta-analysis aims at summarizing and integrating the human
neuroimaging studies that report periaqueductal gray (PAG) involvement; 250 original …
neuroimaging studies that report periaqueductal gray (PAG) involvement; 250 original …
MRI-derived measurements of human subcortical, ventricular and intracranial brain volumes: reliability effects of scan sessions, acquisition sequences, data analyses …
Automated MRI-derived measurements of in-vivo human brain volumes provide novel
insights into normal and abnormal neuroanatomy, but little is known about measurement …
insights into normal and abnormal neuroanatomy, but little is known about measurement …
The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder
AR Aron, RA Poldrack - Biological psychiatry, 2005 - Elsevier
Psychological functions that are behaviorally and neurally well specified may serve as
endophenotypes for attention-deficit/hyperactivity disorder (ADHD) research. Such …
endophenotypes for attention-deficit/hyperactivity disorder (ADHD) research. Such …
Stem cell‐based cell therapy in neurological diseases: a review
SU Kim, J De Vellis - Journal of neuroscience research, 2009 - Wiley Online Library
Human neurological disorders such as Parkinson's disease, Huntington's disease,
amyotrophic lateral sclerosis (ALS), Alzheimer's disease, multiple sclerosis (MS), stroke, and …
amyotrophic lateral sclerosis (ALS), Alzheimer's disease, multiple sclerosis (MS), stroke, and …