Toward a predictive understanding of epithelial cell death

T Cumming, R Levayer - Seminars in Cell & Developmental Biology, 2024 - Elsevier
Epithelial cell death is highly prevalent during development and tissue homeostasis. While
we have a rather good understanding of the molecular regulators of programmed cell death …

Cell polarity and extrusion: How to polarize extrusion and extrude misspolarized cells?

R Staneva, R Levayer - Current Topics in Developmental Biology, 2023 - Elsevier
The barrier function of epithelia is one of the cornerstones of the body plan organization of
metazoans. It relies on the polarity of epithelial cells which organizes along the apico-basal …

[HTML][HTML] Nebivolol, an antihypertensive agent, has new application in inhibiting melanoma

S Yang, Z Li, J Yi, M Pan, W Cao, J Ma… - Anti-Cancer …, 2024 - journals.lww.com
Repurposing existing drugs for cancer therapy has become an important strategy because
of its advantages, such as cost reduction, effect and safety. The present study was designed …

A cell surface code mediates tissue-intrinsic defense against aberrant cells in epithelia

F Fischer, L Ernst, A Frey, K Holstein, D Prasad… - bioRxiv, 2023 - biorxiv.org
Tissue-intrinsic error-correction mechanisms allow epithelial cells to detect aberrant
neighboring cells and cause their removal from the tissue. The molecular mechanisms …

In preprints: get to know your neighbours–cell interface surveillance through a molecular zip code

LD Ríos-Barrera, V Mirouse - Development, 2023 - journals.biologists.com
One of the central questions of developmental biology has been how tissues define patterns
with fixed boundaries, as exemplified by the classical French flag model from Lewis Wolpert …

A mismatch in the expression of cell surface molecules induces tissue-intrinsic defense against aberrant cells

F Fischer, L Ernst, A Frey, K Holstein, D Prasad… - Current Biology, 2024 - cell.com
Tissue-intrinsic error correction enables epithelial cells to detect abnormal neighboring cells
and facilitate their removal from the tissue. One of these pathways," interface surveillance," is …

[HTML][HTML] Genes involved in tissue and organ development

C Niemann-Pick Type - sdbonline.org
The ectodermal derivatives of the gut are the stomodeum and the proctodeum. The
proctodeum is formed concurrently with germ-band elongation [Images] while formation of …