Dicoumarol is an oral anticoagulant agent prescribed in clinical for decades. It is a natural
hydroxycoumarin discovered from the spoilage of Melilotus officinalis (L.) Pall and is …

Abstract Salsolinol (1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline) is a
tetrahydroisoquinoline derivative whose presence in humans was first detected in the urine …

Abstract Endogenous neurotoxin 1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroiso-quinoline
(Salsolinol, SAL) is a dopamine metabolite that is toxic to dopaminergic neurons in vitro and …

Neurotoxins, in the general sense, represent novel chemical structures which when
administered in vivo or in vitro, are capable of producing neuronal damage or …

Catecholamine (dopamine, norepinephrine and epinephrine) synthesizing neurons are
widely distributed in the brain, sympathetic ganglia and throughout peripheral organs …

Although it is generally accepted that free radicals are involved in the neurodegenerative
process occurring in the dopaminergic neurons of the nigro-striatal system in Parkinson's …

We have induced intracellular dopamine oxidation to aminochrome in RCSN-3 cells derived
from rat substantia nigra by inhibiting VMAT-2 with reserpine to increase free cytosolic …

Previous work from our laboratory has focused on mitochondrial DNA (mtDNA) repair and
cellular viability. However, other events occur prior to the initiation of apoptosis in cells …

Sustained high levels of circulating catecholamines may induce cardiotoxicity. There is
increasing evidence that this could result from catecholamine oxidation into aminochromes …

The subject invention pertains to tumor cell lines useful for increasing the proliferation
potential of any human or animal cell in culture, thereby providing immortalized or …