[HTML][HTML] Intestinal absorption of bile acids in health and disease

AL Ticho, P Malhotra, PK Dudeja, RK Gill… - Comprehensive …, 2019 - ncbi.nlm.nih.gov
The intestinal reclamation of bile acids is crucial for the maintenance of their enterohepatic
circulation. The majority of bile acids are actively absorbed via specific transport proteins …

The solute carrier family 10 (SLC10): beyond bile acid transport

TC Da Silva, JE Polli, PW Swaan - Molecular aspects of medicine, 2013 - Elsevier
The solute carrier (SLC) family 10 (SLC10) comprises influx transporters of bile acids,
steroidal hormones, various drugs, and several other substrates. Because the seminal …

The SLC10 carrier family: transport functions and molecular structure

B Döring, T Lütteke, J Geyer, E Petzinger - Current topics in membranes, 2012 - Elsevier
The SLC10 family represents seven genes containing 1–12 exons that encode proteins in
humans with sequence lengths of 348–477 amino acids. Although termed solute carriers …

Oligomeric bile acid-mediated oral delivery of low molecular weight heparin

TA Al-Hilal, J Park, F Alam, SW Chung, JW Park… - Journal of Controlled …, 2014 - Elsevier
Intestinal transporters are limited to the transport of small molecular substrates. Here, we
describe the development of apical sodium-dependent bile acid transporter (ASBT)-targeted …

Resveratrol promotes degradation of the human bile acid transporter ASBT (SLC10A2)

PP Chothe, PW Swaan - Biochemical Journal, 2014 - portlandpress.com
The sodium/bile acid co-transporter ASBT [apical sodium-dependent bile acid transporter;
SLC10A2 (solute carrier family 10 member 2)] plays a key role in the enterohepatic recycling …

Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2)[S]

DA Lionarons, JL Boyer, SY Cai - Journal of lipid research, 2012 - ASBMB
The apical Na+-dependent bile salt transporter (ASBT/SLC10A2) is essential for maintaining
the enterohepatic circulation of bile salts. It is not known when Slc10a2 evolved as a bile salt …

Tyrosine Phosphorylation Regulates Plasma Membrane Expression and Stability of the Human Bile Acid Transporter ASBT (SLC10A2)

PP Chothe, LC Czuba, EN Ayewoh… - Molecular …, 2019 - ACS Publications
The human apical sodium-dependent bile acid transporter (hASBT; SLC 10 A 2) is
responsible for the reclamation of bile acids from the intestinal lumen, providing a primary …

[HTML][HTML] Human bile acid transporter ASBT (SLC10A2) forms functional non-covalent homodimers and higher order oligomers

PP Chothe, LC Czuba, RH Moore… - Biochimica et Biophysica …, 2018 - Elsevier
The human apical sodium-dependent bile acid transporter, hASBT/SLC10A2, plays a central
role in cholesterol homeostasis via the efficient reabsorption of bile acids from the distal …

Ileal apical sodium-dependent bile acid transporter protein levels are down-regulated through ubiquitin-dependent protein degradation induced by bile acids

M Miyata, H Yamakawa, K Hayashi… - European journal of …, 2013 - Elsevier
The ileal apical sodium-dependent bile acid transporter (ASBT or SLC10A2) has a crucial
role in intestinal bile acid absorption. We previously reported that enterobacteria-mediated …

Transmembrane domain V plays a stabilizing role in the function of human bile acid transporter SLC10A2

RH Moore, P Chothe, PW Swaan - Biochemistry, 2013 - ACS Publications
The human apical sodium-dependent bile acid transporter (hASBT, SLC10A2), primarily
expressed in the ileum, is involved in both the recycling of bile acids and cholesterol …