Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?

M Keshavarz, K Xie, K Schaaf, D Bano… - Molecular …, 2023 - nature.com
Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost

YP Zhang, WH Zhang, P Zhang, Q Li, Y Sun… - Nature …, 2022 - nature.com
Twenty-nine years following the breakthrough discovery that a single-gene mutation of daf-2
doubles Caenorhabditis elegans lifespan, it remains unclear where this insulin/IGF-1 …

Neuropeptide inactivation regulates egg-laying behavior to influence reproductive health in Caenorhabditis elegans

JY Lo, KM Adam, JL Garrison - Current Biology, 2024 - cell.com
Neural communication requires both fast-acting neurotransmitters and neuromodulators that
function on slower timescales to communicate. Endogenous bioactive peptides, often called" …

Invited review: Unearthing the mechanisms of age-related neurodegenerative disease using Caenorhabditis elegans

AN Hayden, EJ Leptich, RN Arey - … and Physiology Part A: Molecular & …, 2022 - Elsevier
As human life expectancy increases, neurodegenerative diseases present a growing public
health threat, for which there are currently few effective treatments. There is an urgent need …

Icariin Improves Stress Resistance and Extends Lifespan in Caenorhabditis elegans through hsf-1 and daf-2-Driven Hormesis

MN Todorova, MS Savova, LV Mihaylova… - International Journal of …, 2023 - mdpi.com
Aging presents an increasingly significant challenge globally, driven by the growing
proportion of individuals aged 60 and older. Currently, there is substantial research interest …

Phytochemical Composition and Anti‐Aging Activity of Butanol Extract of Hedyotis diffusa in Caenorhabditis elegans

J Li, D Liu, D Li, Y Guo, H Du, Y Cao - Chemistry & Biodiversity, 2022 - Wiley Online Library
Hedyotis diffusa Willd.(H. diffusa), a kind of traditional Chinese medicine, has been
evaluated to potential display antioxidant and anti‐aging effects in vitro experiments. In this …

Combinatorial transcriptomic and genetic dissection of insulin/IGF‐1 signaling‐regulated longevity in Caenorhabditis elegans

S Ham, SS Kim, S Park, HC Kwon, SG Ha, Y Bae… - Aging …, 2024 - Wiley Online Library
Classical genetic analysis is invaluable for understanding the genetic interactions
underlying specific phenotypes, but requires laborious and subjective experiments to …

High-resolution imaging and analysis of the intestinal bacterial load of Caenorhabditis elegans during early adulthood

F Rezaeianaran, MAM Gijs - RSC advances, 2023 - pubs.rsc.org
We study the presence within the worm Caenorhabditis elegans (C. elegans) of a
fluorescent strain of the worm's bacterial food (Escherichia coli (E. coli) OP50) during early …

WormSpace μ-TAS enabling automated on-chip multi-strain culturing and multi-function imaging of Caenorhabditis elegans at single-worm level on the China Space …

Q Yang, R Zhong, W Chang, K Chen, M Wang, S Yuan… - Lab on a Chip, 2024 - pubs.rsc.org
As a model organism for space biology experiments, Caenorhabditis elegans (C. elegans)
has low demand of life support and strong resistance to unfavorable environments, making …

Timing of TORC1 inhibition dictates Pol III involvement in Caenorhabditis elegans longevity

Y Malik, IG Silva, RR Diazgranados… - Life Science …, 2024 - life-science-alliance.org
Organismal growth and lifespan are inextricably linked. Target of Rapamycin (TOR)
signalling regulates protein production for growth and development, but if reduced, extends …