Drug resistance in epilepsy

E Perucca, P Perucca, HS White, EC Wirrell - The Lancet Neurology, 2023 - thelancet.com
Drug resistance is estimated to affect about a third of individuals with epilepsy, but its
prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other …

Artificial intelligence & clinical nutrition: What the future might have in store

A Bond, K Mccay, S Lal - Clinical nutrition ESPEN, 2023 - Elsevier
Artificial Intelligence (AI) is a rapidly emerging technology in healthcare that has the
potential to revolutionise clinical nutrition. AI can assist in analysing complex data …

[HTML][HTML] Performance evaluation of metaheuristics-tuned recurrent neural networks for electroencephalography anomaly detection

D Pilcevic, M Djuric Jovicic, M Antonijevic… - Frontiers in …, 2023 - frontiersin.org
Electroencephalography (EEG) serves as a diagnostic technique for measuring brain waves
and brain activity. Despite its precision in capturing brain electrical activity, certain factors …

Machine learning and artificial intelligence applications to epilepsy: a review for the practicing epileptologist

WT Kerr, KN McFarlane - Current Neurology and Neuroscience Reports, 2023 - Springer
Abstract Purpose of Review Machine Learning (ML) and Artificial Intelligence (AI) are data-
driven techniques to translate raw data into applicable and interpretable insights that can …

The evolution of antiseizure medication therapy selection in adults: Is artificial intelligence-assisted antiseizure medication selection ready for prime time?

CL Gunasekera, JI Sirven… - Journal of Central …, 2023 - journals.sagepub.com
Antiseizure medications (ASMs) are the mainstay of symptomatic epilepsy treatment. The
primary goal of pharmacotherapy with ASMs in epilepsy is to achieve complete seizure …

[HTML][HTML] Epilepsy: Mitochondrial connections to the 'Sacred'disease

WH Moos, DV Faller, IP Glavas, I Kanara, K Kodukula… - Mitochondrion, 2023 - Elsevier
Over 65 million people suffer from recurrent, unprovoked seizures. The lack of validated
biomarkers specific for myriad forms of epilepsy makes diagnosis challenging. Diagnosis …

Potential merits and flaws of large language models in epilepsy care: a critical review

E van Diessen, RA van Amerongen, M Zijlmans… - …, 2024 - Wiley Online Library
The current pace of development and applications of large language models (LLMs) is
unprecedented and will impact future medical care significantly. In this critical review, we …

Treatment outcomes of newly diagnosed epilepsy: a systematic review and meta-analysis

M Janmohamed, H Hakeem, S Ooi, S Hakami, L Vu… - CNS drugs, 2023 - Springer
Abstract Background and Objectives Understanding the multi-faceted treatment outcomes of
newly diagnosed epilepsy is critical for developing rational therapeutic strategies. A meta …

Artificial intelligence and machine learning in clinical pharmacological research

B Mayer, D Kringel, J Lötsch - Expert Review of Clinical …, 2024 - Taylor & Francis
Background Clinical pharmacology research has always involved computational analysis.
With the abundance of drug-related data available, the integration of artificial intelligence …

Should substitution monotherapy or combination therapy be used after failure of the first antiseizure medication? Observations from a 30‐year cohort study

H Hakeem, BAA Alsfouk, P Kwan, MJ Brodie… - Epilepsia, 2023 - Wiley Online Library
Objectives To assess the temporal trends in the use of second antiseizure (ASM) regimens
and compare the efficacy of substitution monotherapy and combination therapy after failure …