The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

Plant polysaccharides represent a natural source material characterized by high ubiquity,
abundance and biological activities that can be utilised as organic matter in numerous …

Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix
(ECM) maestros involved in the orchestration of multiple cellular events in physiology and …

Glycosaminoglycans (GAGs) are a heterogeneous family of linear polysaccharides which
are composed of a repeating disaccharide unit. They are also linked to core proteins to form …

The extracellular matrix (ECM) has long been regarded as a packing material; supporting
cells within the tissue and providing tensile strength and protection from mechanical stress …

Glycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the
activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has …

Heparin (HP) and heparan sulfate (HS) are linear, anionically charged polysaccharides well-
known for their diverse biological activities. While HP is generally localized in mast cells and …

Abstract Extracellular sulfatase-2 (Sulf-2) influences receptor–ligand binding and
subsequent signaling by chemokines and growth factors, yet Sulf-2 remains unexplored in …

Cell membranes are key interfaces where materials engineering meets biology. Traditionally
regarded as just the location of receptors regulating the uptake of molecules, we now know …

Heparin mimetics are synthetic and semi-synthetic compounds that are highly sulfated,
structurally distinct analogues of glycosaminoglycans. These mimetics are often rationally …