[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease

K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

The stomach in health and disease

RH Hunt, M Camilleri, SE Crowe, EM El-Omar, JG Fox… - Gut, 2015 - gut.bmj.com
The stomach is traditionally regarded as a hollow muscular sac that initiates the second
phase of digestion. Yet this simple view ignores the fact that it is the most sophisticated …

The enteric nervous system in gastrointestinal disease etiology

AM Holland, AC Bon-Frauches, D Keszthelyi… - Cellular and Molecular …, 2021 - Springer
A highly conserved but convoluted network of neurons and glial cells, the enteric nervous
system (ENS), is positioned along the wall of the gut to coordinate digestive processes and …

Transient receptor potential (TRP) channels: a clinical perspective

Y Kaneko, A Szallasi - British journal of pharmacology, 2014 - Wiley Online Library
Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …

Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation

L De Petrocellis, P Orlando, AS Moriello… - Acta …, 2012 - Wiley Online Library
Aim: Plant cannabinoids, like Δ9‐tetrahydrocannabinol (THC) and cannabidiol (CBD),
activate/desensitize thermosensitive transient receptor potential (TRP) channels of vanilloid …

TRPV1 activation counters diet-induced obesity through sirtuin-1 activation and PRDM-16 deacetylation in brown adipose tissue

P Baskaran, V Krishnan, K Fettel, P Gao… - International Journal of …, 2017 - nature.com
Results: CAP antagonized high-fat diet (HFD)-induced obesity without decreasing energy
intake in mice. HFD suppressed TRPV1 expression and activity in BAT and CAP countered …

TRPV4: a physio and pathophysiologically significant ion channel

T Rosenbaum, M Benítez-Angeles… - International journal of …, 2020 - mdpi.com
Transient Receptor Potential (TRP) channels are a family of ion channels whose members
are distributed among all kinds of animals, from invertebrates to vertebrates. The importance …

[HTML][HTML] Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system

P Holzer - Pharmacology & therapeutics, 2011 - Elsevier
Approximately 20 of the 30 mammalian transient receptor potential (TRP) channel subunits
are expressed by specific neurons and cells within the alimentary canal. They subserve …

High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: correlation with pathological parameters

I Dhennin-Duthille, M Gautier, M Faouzi… - Cellular Physiology and …, 2011 - karger.com
Abstract Background: Transient Receptor Potential (TRP) channels are expressed in many
solid tumors. However, their expression in breast cancer remains largely unknown. Here, we …

Food choice as a key management strategy for functional gastrointestinal symptoms

PR Gibson, SJ Shepherd - Official journal of the American College …, 2012 - journals.lww.com
Recognition of food components that induce functional gut symptoms in patient's functional
bowel disorders (FBD) has been challenging. Food directly or indirectly provides …