Inflammatory mediators increase vascular permeability primarily by formation of intercellular
gaps between endothelial cells of post-capillary venules. Under these conditions …

Abstract Sphingosine 1-phosphate (S1P), a lipid mediator produced by sphingolipid
metabolism, promotes endothelial cell spreading, vascular maturation/stabilization, and …

A significant and sustained increase in vascular permeability is a hallmark of acute
inflammatory diseases such as acute lung injury (ALI) and sepsis and is an essential …

The mechanical characteristics of endothelial cells reveal four distinct compartments,
namely glycocalyx, cell cortex, cytoplasm and nucleus. There is accumulating evidence that …

Nonmuscle myosin light chain kinase (nmMLCK), a multi-functional cytoskeletal protein
critical to vascular homeostasis, is highly regulated by tyrosine phosphorylation. We …

Inflammation is the major cause of endothelial barrier hyper‐permeability, associated with
acute lung injury and acute respiratory distress syndrome. This study reports that p53 …

Loss of endothelial barrier function is implicated in the etiology of metastasis,
atherosclerosis, sepsis and many other diseases. Studies suggest that sphingosine-1 …

Primary open-angle glaucoma is associated with elevated intraocular pressure, which in
turn is believed to result from impaired outflow of aqueous humour. Aqueous humour outflow …

The pulmonary endothelial cell forms a critical semi-permeable barrier between the vascular
and interstitial space. As part of the blood-gas barrier in the lung, the endothelium plays a …

Cortactin (CTTN) is an actin-binding and cytoskeletal protein that is found in abundance in
the cell cortex and other peripheral structures of most cell types. It was initially described as …